| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | FEDERATED INVESTORS, INC. | 4,156,692 | 7.16 | $146,731,227 | 30-Sep-09 | | SECTORAL ASSET MANAGEMENT, INC. | 3,122,660 | 5.38 | $110,229,898 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 3,121,958 | 5.38 | $110,205,117 | 30-Sep-09 | | WESTFIELD CAPITAL MANAGEMENT COMPANY | 3,062,853 | 5.28 | $108,118,710 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 2,901,068 | 5.00 | $102,407,700 | 30-Sep-09 | | JANUS CAPITAL MANAGEMENT, LLC | 2,660,117 | 4.58 | $93,902,130 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,245,249 | 3.87 | $79,257,289 | 30-Sep-09 | | FMR LLC | 2,194,970 | 3.78 | $77,482,441 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 1,639,100 | 2.82 | $57,860,230 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 7,776,108 | 13.40 | $274,496,612 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | VANGUARD SPECIALIZED-HEALTH CARE FUND | 3,612,000 | 6.22 | $122,049,480 | 31-Jul-09 | | FEDERATED KAUFMANN FUND | 3,600,000 | 6.20 | $121,644,000 | 31-Jul-09 | | Janus Research Fund | 1,114,505 | 1.92 | $39,342,026 | 30-Sep-09 | | LORD ABBETT RESEARCH FUND, SMALL-CAP VALUE SERIES | 990,200 | 1.71 | $33,072,680 | 31-Aug-09 | | PRICE (T.ROWE) MID CAP GROWTH FUND | 900,000 | 1.55 | $31,770,000 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 703,306 | 1.21 | $19,854,328 | 30-Jun-09 | | FIDELITY MAGELLAN FUND INC | 698,900 | 1.20 | $24,671,170 | 30-Sep-09 | | PRICE (T.ROWE) NEW HORIZONS FUND | 583,100 | 1.00 | $20,583,430 | 30-Sep-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 575,000 | .99 | $20,297,500 | 30-Sep-09 | | SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 562,086 | .97 | $15,867,687 | 30-Jun-09 |
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*
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Value shown is computed using the security's price on the report date given.
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