| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | COLUMBIA WANGER ASSET MANAGEMENT, L.P. | 2,214,000 | 6.33 | $16,560,720 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 1,198,339 | 3.43 | $8,963,575 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 964,456 | 2.76 | $7,214,130 | 30-Sep-09 | | TCW GROUP, INC. (THE) | 953,806 | 2.73 | $7,134,468 | 30-Sep-09 | | ORACLE INVESTMENT MANAGEMENT, INC. | 950,000 | 2.72 | $7,106,000 | 30-Sep-09 | | KINGDON CAPITAL MANAGEMENT LLC | 900,000 | 2.57 | $6,732,000 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 862,176 | 2.47 | $6,449,076 | 30-Sep-09 | | MPM Asset Management, LLC | 6,363,249 | 18.20 | $11,644,745 | 31-Dec-09 | | FMR LLC | 493,560 | 1.41 | $3,691,828 | 30-Sep-09 | | SHAW D.E. & CO., INC. | 463,737 | 1.33 | $3,468,752 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | COLUMBIA ACORN FD | 1,450,916 | 4.15 | $10,852,851 | 30-Sep-09 | | PRICE (T.ROWE) HEALTH SCIENCES FUND | 749,998 | 2.15 | $5,609,985 | 30-Sep-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 634,360 | 1.81 | $3,787,129 | 30-Jun-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 305,921 | .88 | $645,493 | 30-Nov-09 | | ISHARES RUSSELL 2000 INDEX FD | 303,196 | .87 | $639,743 | 30-Nov-09 | | COLUMBIA ACORN USA FD | 290,184 | .83 | $2,170,576 | 30-Sep-09 | | Wanger Advisor Trust-Wanger USA, Variable Series | 270,800 | .77 | $2,025,584 | 30-Sep-09 | | TCW SMALL CAP GROWTH FUND | 232,400 | .66 | $1,675,604 | 31-Jul-09 | | GENERAL AMERICAN INVESTORS CO | 195,344 | .56 | $1,461,173 | 30-Sep-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 190,717 | .55 | $1,138,580 | 30-Jun-09 |
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*
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Value shown is computed using the security's price on the report date given.
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