| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | SHAW D.E. & CO., INC. | 2,516,671 | 7.92 | $5,259,842 | 30-Sep-09 | | FRANKLIN RESOURCES, INC | 1,803,565 | 5.68 | $3,769,450 | 30-Sep-09 | | FEDERATED INVESTORS, INC. | 1,471,273 | 4.63 | $3,074,960 | 30-Sep-09 | | HAMBRECHT & QUIST CAPITAL MANAGEMENT, INC. | 963,239 | 3.03 | $2,013,169 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 838,386 | 2.64 | $1,752,226 | 30-Sep-09 | | DiamondBack Capital Management | 744,900 | 2.35 | $1,556,841 | 30-Sep-09 | | PERCEPTIVE ADVISORS LLC | 4,626,446 | 14.57 | $9,669,272 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 550,152 | 1.73 | $1,149,817 | 30-Sep-09 | | GRUBER & MCBAINE CAPITAL MANAGEMENT LLC | 513,530 | 1.62 | $1,073,277 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 504,033 | 1.59 | $1,053,428 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FEDERATED KAUFMANN SMALL CAP FUND | 1,101,700 | 3.47 | $3,018,658 | 31-Jul-09 | | H&Q HEALTHCARE INVESTORS | 574,211 | 1.81 | $941,706 | 31-Mar-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 513,499 | 1.62 | $1,463,472 | 30-Jun-09 | | H&Q LIFE SCIENCES INVESTORS | 399,028 | 1.26 | $654,405 | 31-Mar-09 | | FRANKLIN STRATEGIC SERIES-FRANKLIN BIOTECHNOLOGY DISCOVE | 369,400 | 1.16 | $772,046 | 30-Sep-09 | | FRANKLIN STRATEGIC SERIES-SMALL CAP GROWTH FUND | 354,000 | 1.11 | $739,860 | 30-Sep-09 | | Advanced Series Tr-AST/Federated Aggressive Growth Port | 340,073 | 1.07 | $969,208 | 30-Jun-09 | | DFA U.S. MICRO CAP SERIES | 278,634 | .88 | $456,959 | 30-Apr-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 276,807 | .87 | $788,899 | 30-Jun-09 | | GABELLI SMALL CAP GROWTH FUND | 155,000 | .49 | $323,950 | 30-Sep-09 |
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Value shown is computed using the security's price on the report date given.
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