| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Visium Asset Management | 1,202,379 | 6.53 | $22,027,583 | 30-Sep-09 | | Andreeff Equity Advisors, L.L.C. | 1,199,492 | 6.51 | $21,974,693 | 30-Sep-09 | | JENNISON ASSOCIATES LLC | 789,793 | 4.29 | $14,469,007 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 571,100 | 3.10 | $10,462,552 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 5,146,589 | 27.95 | $94,285,510 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 550,531 | 2.99 | $10,085,727 | 30-Sep-09 | | FMR LLC | 2,741,640 | 14.89 | $50,226,844 | 30-Sep-09 | | FRANKLIN RESOURCES, INC | 320,200 | 1.74 | $5,866,064 | 30-Sep-09 | | Invesco Ltd. | 282,740 | 1.54 | $5,179,796 | 30-Sep-09 | | SECTORAL ASSET MANAGEMENT, INC. | 279,295 | 1.52 | $5,116,684 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY CONTRAFUND INC | 662,704 | 3.60 | $12,140,737 | 30-Sep-09 | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 626,395 | 3.40 | $11,112,247 | 31-Aug-09 | | Fidelity Small Cap Growth Fund | 327,000 | 1.78 | $6,369,960 | 31-Jul-09 | | Fidelity Small Cap Opportunities Fund | 258,000 | 1.40 | $5,025,840 | 31-Jul-09 | | FIDELITY SELECT PORTFOLIOS - HEALTH CARE | 249,800 | 1.36 | $4,576,336 | 30-Sep-09 | | VARIABLE INSURANCE PRODUCTS FD II-CONTRAFUND PORTFOLIO | 224,600 | 1.22 | $4,114,672 | 30-Sep-09 | | VARIABLE INSURANCE PRODUCTS FD III-MID-CAP PORTFOLIO | 219,966 | 1.19 | $4,029,777 | 30-Sep-09 | | ISHARES RUSSELL 2000 INDEX FD | 208,955 | 1.13 | $3,828,055 | 30-Sep-09 | | FIDELITY BALANCED FUND | 171,700 | .93 | $3,145,544 | 30-Sep-09 | | FRANKLIN STRATEGIC SERIES-FRANKLIN BIOTECHNOLOGY DISCOVE | 169,012 | .92 | $3,096,299 | 30-Sep-09 |
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Value shown is computed using the security's price on the report date given.
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