| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BAKER BROTHERS ADVISORS, LLC | 4,801,442 | 9.73 | $102,078,656 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 4,161,518 | 8.43 | $88,473,872 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 4,086,119 | 8.28 | $86,870,889 | 30-Sep-09 | | MORGAN STANLEY | 3,673,829 | 7.45 | $78,105,604 | 30-Sep-09 | | S.A.C. CAPITAL ADVISORS, LLC | 2,600,000 | 5.27 | $55,276,000 | 30-Sep-09 | | Visium Asset Management | 2,503,872 | 5.07 | $53,232,318 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,108,736 | 4.27 | $44,831,727 | 30-Sep-09 | | CR Intrinsic Investors, LLC | 1,233,380 | 2.50 | $26,221,658 | 30-Sep-09 | | STATE STREET CORPORATION | 1,181,237 | 2.39 | $25,113,098 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 5,050,626 | 10.24 | $107,376,308 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | ISHARES RUSSELL 2000 INDEX FD | 708,142 | 1.44 | $15,055,098 | 30-Sep-09 | | ISHARES S&P SMALLCAP 600 INDEX FD | 632,531 | 1.28 | $11,632,245 | 31-Oct-09 | | VANGUARD SMALL-CAP INDEX FUND | 586,995 | 1.19 | $5,793,640 | 30-Jun-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 471,251 | .96 | $8,666,305 | 31-Oct-09 | | HARTFORD SMALLCAP GROWTH HLS SERIES | 463,000 | .94 | $4,569,810 | 30-Jun-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 458,397 | .93 | $4,524,378 | 30-Jun-09 | | DFA U.S. SMALL CAP VALUE SERIES | 444,736 | .90 | $4,892,096 | 30-Apr-09 | | IShares S&P Small Cap 600 Growth Index Fund | 372,309 | .75 | $6,846,762 | 31-Oct-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 371,028 | .75 | $3,662,046 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 370,530 | .75 | $7,877,467 | 30-Sep-09 |
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*
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Value shown is computed using the security's price on the report date given.
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