| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Barclays Global Investors UK Holdings Ltd | 3,098,315 | 5.15 | $8,272,501 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 2,555,906 | 4.25 | $6,824,269 | 30-Sep-09 | | WISCONSIN (STATE OF) INVESTMENT BOARD | 1,737,021 | 2.89 | $4,637,846 | 30-Sep-09 | | BVF INC. | 6,171,399 | 10.26 | $16,477,635 | 30-Sep-09 | | STATE STREET CORPORATION | 985,066 | 1.64 | $2,630,126 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 883,230 | 1.47 | $2,358,224 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 751,020 | 1.25 | $2,005,223 | 30-Sep-09 | | WALL STREET ASSOCIATES | 618,500 | 1.03 | $1,651,395 | 30-Sep-09 | | TIAA-CREF INVESTMENT MANAGEMENT, LLC | 443,492 | .74 | $1,184,123 | 30-Sep-09 | | ICC CAPITAL MANAGEMENT, INC. | 346,000 | .58 | $923,820 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | ISHARES RUSSELL 2000 INDEX FD | 870,143 | 1.45 | $2,323,281 | 30-Sep-09 | | DFA U.S. SMALL CAP VALUE SERIES | 678,609 | 1.13 | $1,364,004 | 30-Apr-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 518,818 | .86 | $1,214,034 | 31-Oct-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 508,837 | .85 | $1,027,850 | 30-Jun-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 308,583 | .51 | $623,337 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 292,323 | .49 | $780,502 | 30-Sep-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 194,766 | .32 | $393,427 | 30-Jun-09 | | ISHARES RUSSELL 2000 VALUE INDEX FD | 170,108 | .28 | $454,188 | 30-Sep-09 | | BRIDGEWAY FDS INC-ULTRA SMALL COMPANY MARKET FD | 168,600 | .28 | $340,572 | 30-Jun-09 | | Ivy Fds VIP-Micro Cap Growth Port | 121,700 | .20 | $245,834 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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