| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Visium Asset Management | 1,922,194 | 6.94 | $41,077,285 | 30-Sep-09 | | NOMURA HOLDINGS INC. | 796,143 | 2.87 | $17,013,575 | 30-Sep-09 | | FMR LLC | 3,392,125 | 12.25 | $72,489,711 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 3,150,082 | 11.37 | $67,317,252 | 30-Sep-09 | | BVF INC. | 2,882,925 | 10.41 | $61,608,107 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 530,355 | 1.91 | $11,333,686 | 30-Sep-09 | | PERCEPTIVE ADVISORS LLC | 347,700 | 1.26 | $7,430,349 | 30-Sep-09 | | JENNISON ASSOCIATES LLC | 338,800 | 1.22 | $7,240,156 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 297,708 | 1.07 | $6,362,019 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 277,904 | 1.00 | $5,938,808 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY CONTRAFUND INC | 1,112,469 | 4.02 | $23,773,462 | 30-Sep-09 | | FIDELITY ADVISOR NEW INSIGHTS FUND | 1,030,600 | 3.72 | $22,023,922 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 386,076 | 1.39 | $8,250,444 | 30-Sep-09 | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 246,600 | .89 | $3,674,340 | 31-Aug-09 | | FIDELITY SELECT PORTFOLIOS - HEALTH CARE | 231,191 | .83 | $4,940,551 | 30-Sep-09 | | FIDELITY CAPITAL APPRECIATION FUND | 163,049 | .59 | $3,484,357 | 30-Sep-09 | | FIDELITY OTC PORTFOLIO | 86,722 | .31 | $1,853,249 | 30-Sep-09 | | FIDELITY ADVISOR HEALTH CARE FUND | 60,098 | .22 | $1,284,294 | 30-Sep-09 | | DFA TAX-MANAGED U.S. SMALL CAP PORTFOLIO | 58,828 | .21 | $631,224 | 31-Jul-09 | | Fidelity Asset Manager 50% | 53,195 | .19 | $1,136,777 | 30-Sep-09 |
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*
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Value shown is computed using the security's price on the report date given.
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