| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BBT Capital Management, Inc. | 425,000 | 3.18 | $5,865,000 | 30-Sep-09 | | BVF INC. | 301,454 | 2.25 | $4,160,065 | 30-Sep-09 | | FRANKLIN RESOURCES, INC | 251,600 | 1.88 | $3,472,080 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 76,840 | .57 | $1,060,392 | 30-Sep-09 | | PALO ALTO INVESTORS, LLC | 56,508 | .42 | $779,810 | 30-Sep-09 | | WELLS FARGO & COMPANY | 55,155 | .41 | $761,139 | 30-Sep-09 | | RENAISSANCE TECHNOLOGIES, LLC | 39,519 | .30 | $545,362 | 30-Sep-09 | | NORTHERN TRUST CORPORATION | 35,127 | .26 | $484,752 | 30-Sep-09 | | NUMERIC INVESTORS, LLC | 25,165 | .19 | $347,277 | 30-Sep-09 | | CR Intrinsic Investors, LLC | 20,000 | .15 | $276,000 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FRANKLIN STRATEGIC SERIES-FRANKLIN BIOTECHNOLOGY DISCOVE | 95,600 | .71 | $1,319,280 | 30-Sep-09 | | FRANKLIN STRATEGIC SERIES-SMALL CAP GROWTH FUND | 57,100 | .43 | $787,980 | 30-Sep-09 | | DFA TAX-MANAGED U.S. SMALL CAP PORTFOLIO | 13,699 | .10 | $79,454 | 31-Jul-09 | | ISHARES Russell Micro Cap (TM) Index Fund | 8,297 | .06 | $45,550 | 31-Oct-09 | | DFA U.S. SMALL CAP SERIES | 6,500 | .05 | $37,700 | 31-Jul-09 | | DFA U.S. SMALL CAP VALUE SERIES | 5,118 | .04 | $29,684 | 31-Jul-09 | | SPARTAN EXTENDED MARKET INDEX FUND | 3,984 | .03 | $21,872 | 31-Oct-09 | | DFA U.S. Core Equity 1 Portfolio | 1,700 | .01 | $9,860 | 31-Jul-09 | | FIDELITY NASDAQ COMPOSITE INDEX FUND | 1,571 | .01 | $8,624 | 31-Oct-09 | | DFA T.A. U.S. Core Equity 2 Portfolio | 1,040 | .01 | $6,032 | 31-Jul-09 |
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Value shown is computed using the security's price on the report date given.
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