| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | SECTORAL ASSET MANAGEMENT, INC. | 3,793,226 | 7.05 | $185,830,141 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 2,491,757 | 4.63 | $122,071,175 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,840,012 | 3.42 | $90,142,187 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 1,823,520 | 3.39 | $89,334,244 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 1,526,897 | 2.84 | $74,802,684 | 30-Sep-09 | | DEUTSCHE BANK AKTIENGESELLSCHAFT | 1,460,257 | 2.71 | $71,537,990 | 30-Sep-09 | | STATE STREET CORPORATION | 1,441,940 | 2.68 | $70,640,640 | 30-Sep-09 | | TURNER INVESTMENT PARTNERS, INC. | 1,431,355 | 2.66 | $70,122,081 | 30-Sep-09 | | Invesco Ltd. | 1,293,796 | 2.40 | $63,383,066 | 30-Sep-09 | | FMR LLC | 7,826,250 | 14.54 | $383,407,987 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY MAGELLAN FUND INC | 1,467,550 | 2.73 | $71,895,274 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 1,162,250 | 2.16 | $56,938,627 | 30-Sep-09 | | FIDELITY INDEPENDENCE FUND | 800,000 | 1.49 | $39,192,000 | 30-Sep-09 | | FIDELITY PURITAN FUND INC | 636,000 | 1.18 | $31,157,640 | 30-Sep-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 600,000 | 1.11 | $29,394,000 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 529,630 | .98 | $22,530,460 | 31-Oct-09 | | VARIABLE INSURANCE PRODUCTS FD-GROWTH PORTFOLIO | 519,540 | .96 | $25,452,264 | 30-Sep-09 | | FIDELITY ADVISOR EQUITY GROWTH FUND | 456,674 | .85 | $22,372,459 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - HEALTH CARE | 450,600 | .84 | $22,074,894 | 30-Sep-09 | | COLUMBIA ACORN FD | 400,000 | .74 | $33,332,000 | 30-Jun-09 |
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*
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Value shown is computed using the security's price on the report date given.
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