| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Barclays Global Investors UK Holdings Ltd | 6,251,726 | 8.07 | $60,141,604 | 30-Sep-09 | | PALO ALTO INVESTORS, LLC | 4,317,511 | 5.58 | $41,534,455 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 3,381,317 | 4.37 | $32,528,269 | 30-Sep-09 | | STATE STREET CORPORATION | 2,412,261 | 3.11 | $23,205,950 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 2,387,968 | 3.08 | $22,972,252 | 30-Sep-09 | | SIGMA CAPITAL MANAGEMENT, LLC | 2,010,600 | 2.60 | $19,341,972 | 30-Sep-09 | | Bank of New York Mellon Corporation | 1,698,717 | 2.19 | $16,341,657 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 1,622,936 | 2.10 | $15,612,644 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 9,405,977 | 12.15 | $90,485,498 | 30-Sep-09 | | FMR LLC | 8,245,830 | 10.65 | $79,324,884 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | ROYCE LOW-PRICED STOCK FUND | 1,588,100 | 2.05 | $9,417,433 | 30-Jun-09 | | ISHARES RUSSELL 2000 INDEX FD | 1,137,982 | 1.47 | $10,947,386 | 30-Sep-09 | | ISHARES S&P SMALLCAP 600 INDEX FD | 1,007,073 | 1.30 | $7,593,330 | 31-Oct-09 | | VANGUARD SMALL-CAP INDEX FUND | 961,247 | 1.24 | $5,700,194 | 30-Jun-09 | | FIDELITY SELECT PORTFOLIOS - HEALTH CARE | 809,748 | 1.05 | $7,789,775 | 30-Sep-09 | | Fidelity Small Cap Growth Fund | 800,000 | 1.03 | $5,896,000 | 31-Jul-09 | | JNL Variable LLC-JNL/Mellon Cap JNL 5 Fd | 736,000 | .95 | $4,364,480 | 30-Jun-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 731,782 | .94 | $4,339,467 | 30-Jun-09 | | FIDELITY DIVIDEND GROWTH FUND | 730,900 | .94 | $7,031,258 | 30-Sep-09 | | FIDELITY SMALL CAP INDEPENDENCE FUND | 705,400 | .91 | $5,198,798 | 31-Jul-09 |
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Value shown is computed using the security's price on the report date given.
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