| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | QVT Financial LP | 2,737,913 | 9.68 | $57,879,480 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 2,304,999 | 8.15 | $48,727,678 | 30-Sep-09 | | FMR LLC | 2,021,936 | 7.15 | $42,743,727 | 30-Sep-09 | | MORGAN STANLEY | 1,882,636 | 6.66 | $39,798,925 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 1,645,121 | 5.82 | $34,777,857 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 1,342,899 | 4.75 | $28,388,884 | 30-Sep-09 | | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,155,700 | 4.09 | $24,431,498 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 1,109,699 | 3.92 | $23,459,036 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 950,530 | 3.36 | $20,094,204 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 770,733 | 2.73 | $16,293,295 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY GROWTH COMPANY FUND | 2,365,436 | 8.36 | $44,422,888 | 31-Oct-09 | | PRICE (T.ROWE) NEW HORIZONS FUND | 996,200 | 3.52 | $21,059,668 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 576,480 | 2.04 | $10,826,294 | 31-Oct-09 | | PRICE (T.ROWE) SMALL CAP STOCK FUND | 531,800 | 1.88 | $11,242,252 | 30-Sep-09 | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 321,000 | 1.14 | $6,028,380 | 31-Oct-09 | | ISHARES RUSSELL 2000 INDEX FD | 279,534 | .99 | $5,249,648 | 31-Oct-09 | | PRICE (T.ROWE) HEALTH SCIENCES FUND | 262,700 | .93 | $2,955,375 | 30-Jun-09 | | VANGUARD SMALL-CAP INDEX FUND | 256,163 | .91 | $2,881,833 | 30-Jun-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 162,563 | .57 | $1,828,833 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 158,428 | .56 | $2,975,277 | 31-Oct-09 |
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*
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Value shown is computed using the security's price on the report date given.
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