| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | PRICE (T.ROWE) ASSOCIATES INC | 2,810,039 | 9.26 | $59,657,127 | 30-Sep-09 | | SECTORAL ASSET MANAGEMENT, INC. | 2,617,400 | 8.63 | $55,567,402 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 1,731,221 | 5.71 | $36,753,821 | 30-Sep-09 | | MAVERICK CAPITAL LTD. | 1,548,614 | 5.10 | $32,877,075 | 30-Sep-09 | | MORGAN STANLEY | 1,283,345 | 4.23 | $27,245,414 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,032,727 | 3.40 | $21,924,794 | 30-Sep-09 | | Capital World Investors | 1,000,000 | 3.30 | $21,230,000 | 30-Sep-09 | | FMR LLC | 987,701 | 3.26 | $20,968,892 | 30-Sep-09 | | JANUS CAPITAL MANAGEMENT, LLC | 961,124 | 3.17 | $20,404,662 | 30-Sep-09 | | JENNISON ASSOCIATES LLC | 821,433 | 2.71 | $17,439,022 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | SMALLCAP WORLD FUND | 1,000,000 | 3.30 | $23,170,000 | 30-Jun-09 | | PRICE (T.ROWE) NEW HORIZONS FUND | 787,200 | 2.59 | $16,712,256 | 30-Sep-09 | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 684,500 | 2.26 | $12,478,435 | 31-Aug-09 | | PRICE (T.ROWE) SMALL CAP STOCK FUND | 585,000 | 1.93 | $12,419,550 | 30-Sep-09 | | PRICE (T.ROWE) HEALTH SCIENCES FUND | 489,300 | 1.61 | $11,337,081 | 30-Jun-09 | | ISHARES RUSSELL 2000 INDEX FD | 438,275 | 1.44 | $9,304,578 | 30-Sep-09 | | JANUS GLOBAL LIFE SCIENCES FUND | 412,799 | 1.36 | $8,763,722 | 30-Sep-09 | | Fidelity Small Cap Growth Fund | 341,000 | 1.12 | $6,820,000 | 31-Jul-09 | | Legg Mason Partners Mid Cap Core Fd | 336,000 | 1.11 | $7,133,280 | 30-Sep-09 | | MORGAN STANLEY INST FD INC-SMALL COMPANY GROWTH PORT | 335,787 | 1.11 | $7,780,184 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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Major Holders
