| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BB BIOTECH AG | 6,000,000 | 8.66 | $36,240,000 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 4,975,036 | 7.18 | $30,049,217 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 3,662,701 | 5.29 | $22,122,714 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 3,055,430 | 4.41 | $18,454,797 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,527,545 | 2.20 | $9,226,371 | 30-Sep-09 | | NORDEA INVESTMENT MANAGEMENT BANK DENMARK A/S | 1,087,353 | 1.57 | $6,567,612 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 977,433 | 1.41 | $5,903,695 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 809,208 | 1.17 | $4,887,616 | 30-Sep-09 | | STATE STREET CORPORATION | 689,175 | .99 | $4,162,617 | 30-Sep-09 | | GRANAHAN INVESTMENT MANAGEMENT INC. | 633,060 | .91 | $3,823,682 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 717,476 | 1.04 | $3,336,263 | 31-Oct-09 | | ISHARES RUSSELL 2000 INDEX FD | 551,804 | .80 | $3,332,896 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 462,008 | .67 | $2,125,236 | 30-Jun-09 | | DFA U.S. SMALL CAP VALUE SERIES | 377,727 | .55 | $1,322,044 | 30-Apr-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 337,855 | .49 | $1,554,133 | 30-Jun-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 290,519 | .42 | $1,336,387 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 288,537 | .42 | $1,742,763 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 248,605 | .36 | $1,501,574 | 30-Sep-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 247,001 | .36 | $1,136,204 | 30-Jun-09 | | WASATCH SMALL CAP GROWTH FUND | 205,700 | .30 | $946,220 | 30-Jun-09 |
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*
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Value shown is computed using the security's price on the report date given.
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