Synta Pharmaceuticals Corp., a biopharmaceutical company, focuses on the discovery, development, and commercialization of small molecule drugs for treating severe medical conditions, including cancer and chronic inflammatory diseases. The company has two drug candidates in clinical trials for treating multiple types of cancer and various drug candidates in the preclinical stage of development. Its oncology product pipeline includes Ganetespib, an Hsp90 inhibitor, which is in Phase III clinical trials for the treatment of second-line advanced adenocarcinoma non-small cell lung cancer (NSCLC) with adenocarcinoma histology; in Phase IIb/III clinical trials for the treatment of adenocarcinoma NSCLC; in Phase II clinical trials for NSCLC patients whose tumors have a genetic profile characterized by rearrangement of the ALK gene and patients with newly diagnosed HER2+ and triple-negative metastatic breast cancer; in Phase II clinical trials for the treatment of breast cancer, lung cancer, acute myeloid leukemia (AML), and rectal cancer; and in Phase I/II clinical trials for treating mesothelioma and multiple myeloma, as well as has completed Phase II clinical trials for treating NSCLC. The company’s product pipeline also comprises additional Hsp90 inhibitors, which are in preclinical development stage for cancer; Elesclomol, a mitochondria-targeting agent that is in Phase I/II clinical trials for ovarian cancer and Phase I clinical trials for AML; and STA-9584, a vascular disrupting agent in preclinical development stage for prostate cancer. Its product pipeline for inflammatory diseases includes CRACM ion channel inhibitors in preclinical development stage for autoimmune diseases, respiratory conditions, and transplantation; and IL-12/23 inhibitors in lead optimization stage for autoimmune diseases. Synta Pharmaceuticals Corp. was incorporated in 2000 and is based in Lexington, Massachusetts.

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