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Geron Corporation (GERN)


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2.77-0.24 (-7.97%)
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  • Notice of settlement in the class action lawsuit has arrived in the mailboxes of most shareholders. This is likely the reason for Friday's 8% drop. The settlement is $6.25 million and relates to Geron's failure to disclose the liver function test result to the public. While the liver issues were minor and later shown to be reversible, the FDA did halt the trial for a short period of time causing the stock to drop over 61%. The liver function test issue is far behind us as Johnson and Johnson forges ahead with Imetelstat, expecting re-occurring annual sales of $1 billion. This settlement in going to look like a small blip in the rear-view mirror as imetestat reaches approval.
  • JJ is not into surprise announcements. Slow, methodical and ultra conservative. So don't see a "shock the shorts" event happening.
    IMO, No reason, at this point , that they would decline a phase 3 or "opt out", So we can pretty much see the event(s) horizon: Phase 3, FDA approval, Marketing expanded to the States and beyond. Milestone payments to G along the way, and a beginning of the 15-20 % profit, coming to G from the sale of IMET. JJ already has a substancial %, why go for a B/O?
    Just speculation of course. A white(or black) swan could appear along the way.
  • Like Toaster said, FDA commissioner Gottlieb said generics cost too much sending drug stocks down. All we need to know is Geron was listed as one of the top ten new drugs AT THEIR LAST CONFERENCE. $$$$
  • The Complete Picture--- (Geron, Mayo Clinic, Yale, Janssen, Abbie) with posted clinical successes and preclinical promising developments. The whole platform looks like a success from early developments to remissions and cures to the potential of combinations. With clinlcal success in humans, and preclinical successes in the science and in animals, Imetelstat continues to impress.

    ODD (orphan) status has already been granted to Janssen (JNJ) by the FDA & EMA, and there is no medical reason to prevent advanced approvals. JNJ has all of the data, trials and analyses of Imetelstat, and all of the news, including potential combinations, safety, and patients' needs, appears to be good.
  • 712,429 shorted GERN shares Friday. The shorts can not keep this up. See the web site below.
    http://nakedshortreport.com/?index=GERN
    Date Close High Low Volume Short Volume % of Vol Shorted
    May 26 NA NA NA 1,130,858 712,429 63.00%

    Naked Short Report, Nasdaq and NYSE Naked Short Positions, Short Selling Interest
    Naked Short Report - track short selling interest on NASDAQ and NYSE STOCKS, check daily short interest, naked short data and short squeeze stock perfomance
    nakedshortreport.com
  • Johnson and Johnson Analyst Day.
    Imetelstat is an exciting first-of-its-kind compound. What attracted J&J to Geron (NASDAQ: GERN), the developer of imetelstat, was its success in phase 1 studies. No prior therapy had led to a partial or complete response in myelofibrosis patients, which is exactly what imetelstat did. In fact, the only FDA-approved drug on the market right now for myelofibrosis focuses on its symptoms (enlarged spleen and anemia) but does nothing to slow disease progression. With interim data on imetelstat looking promising for the higher 9.4 mg/kg dose, Geron and J&J have to be excited about its potential.

    Analysts walking away from J&J's investor presentation, along with shareholders, have to be pleased with the progress the company is making.
  • An "Internet troll" or "Forum Troll" or "Message Board Troll" is a person who posts outrageous message to bait people to answer. Forum Troll delights in sowing discord on the forums. A troll is someone who inspires flaming rhetoric, someone who is purposely provoking and pulling people into flaming discussion. Flaming discussions usually end with name calling and a flame war.
  • Imetelstat for treatment of myelofibrosis(repost)
    Mount Sinai Abstract Received September 14, 2016

    http://www.tandfonline.com/doi/abs/10.1080/21678707.2017.1266934?journalCode=ieod20
    Expert opinion: Results from a single institution pilot study of imetelstat therapy have been reported and indicate a signal of activity. This approach appears to have the potential to reverse bone marrow histomorphologic abnormalities, induce molecular responses, and target the malignant hematopoietic stem cell population in MF patients. Results from a randomized, multi-center, phase II trial in MF are ongoing.

    *************************************************************************************************************************************

    There are 3 New York CT for PMF CT. One of them might be Mount Sinai. Mount Sinai is part of the Imetelstat MDS CT.
    IMO, if Mount Sinai came out with this Opinion, this goes a long way for Imetelstat progress.

    Imetelstat for treatment of myelofibrosis
    (2017). Imetelstat for treatment of myelofibrosis. Expert Opinion on Orphan Drugs: Vol. 5, No. 1, pp. 91-97. doi: 10.1080/21678707.2017.1266934
    www.tandfonline.com
  • What does this really say about the ROAD AHEAD for imetelstat? Some time ago I reported to recruiting for oligonucleotide chemist by Janssen with a link. The corrupt controlling factions on this board tried their damnedest to beat my ears back. Stock is over-sold and undervalued:

    JSC Schaffhausen Receives Approval for Launch of Innovative Cancer Drug

    Janssen Supply Chain Schaffhausen has reached a milestone in the product launch of an innovative cancer drug. The Global Sourcing Committee of Janssen Supply Chain has given the site in Schaffhausen the approval for launch of IMETELSTAT (the name of an active pharmaceutical ingredient), a lyophilized product. [ I had reported it was lyophilized with stability of 3 years.]

    http://jnj.ch/int/ch/newsletter/4_15/en/jsc-schaffhausen.html

    JSC Schaffhausen
    jnj.ch
  • Can't find any news to go with the drop today..
  • Large Institutional Holdings

    From December 31, 2015 to March 31, 2017

    Fidelity. 23,721,325 23,709,425

    Blackrock 10,687,317. 11,939,814

    Vanguard 5,673,685 7,112,183

    State Street. 4,716,857 4,667,878

    Large Institutions are likely to add more shares or remain about the same. Short Player is playing his hand out but one thing he does not know is who is buying the shares he just sold.
  • Thank you Commissioner Gottlieb for your announcement today regarding cost control of generic drugs, and dealing a nasty body slam to pharmaceutical share prices today. However, your comments are essentially irrelevant to Geron's imetelstat which is not a generic drug, and won't be for decades!
  • Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor

    ClinicalTrials gov Identifier:
    NCT02426086
    First received: April 21, 2015
    Last updated: October 31, 2016
    Last verified: October 2016
    History of Changes

    Sponsor: Janssen Research & Development, LLC
    Information provided by (Responsible Party): Janssen Research & Development, LLC

    Purpose
    The purpose of this study is to evaluate the percentage of spleen (largest lymph organ in the body) response and symptom response of 2 dose regimens of imetelstat in participants with intermediate-2 or high-risk myelofibrosis (MF) who are relapsed after or refractory to Janus Kinase (JAK) inhibitor treatment.

    Condition Intervention Phase
    Primary Myelofibrosis
    Drug: Imetelstat 9.4 milligram/kilogram (mg/kg)
    Drug: Imetelstat 4.7 mg/kg
    Phase 2

    Study Type: Interventional
    Study Design: Allocation: Randomized
    Intervention Model: Parallel Assignment
    Masking: Open Label
    Primary Purpose: Treatment
    Official Title: A Randomized, Single-Blind, Multicenter Phase 2 Study to Evaluate the Activity of 2 Dose Levels of Imetelstat in Subjects With Intermediate-2 or High-Risk Myelofibrosis (MF) Relapsed/Refractory to Janus Kinase (JAK) Inhibitor
  • Jackdaw/Joe/Curt/etc., lay off the all caps. "Report"? Report what? Your reptile alien theories? Yeah, you give the SEC a call and tell them that undocumented heterothermo-Americans are using their magic wands to change the price of GERN stock. See how that goes for you.

    You were fine when the price of GERN went UP on no data, but now you're suddenly concerned that price movement is "suspicious". The price of a no-earnings biotech can go anywhere it wants until there is a drug approval. If you don't get that, then put your retirement money in the index (and watch as Trump takes that down too).
  • Why is it that I can't put some posters on mute? No matter what or how many time they are muted or reported they keep re-appearing. Have William's reptilian aliens once again hacked into the Yahoo/Verizon mainframe and taken over?
  • This post from me is just a sort of heads up..I keep a close watch on the Options action of Geron and especially the open interest of every month at expiration..The last month that had a high count of open interest options was January 2017...there were over 25,000 Call Options open interest of the strike ranging from 1 up to 7..Guess what happened? Almost EVERY ONE of those options expired worthless except for the 1's as they took Geron down below 2 at expiration Friday on Jan 20..These Mother F***ers are good at what they do..

    So now we have over 15,000 open interest Call Options set to expire on June 16...What will they come up with to get Geron down to the 2 strike?

    There's 6,187 of the strike 2 open interest count.
    4,124 of the 3 strike
    2,351 of the 4 strike
    1,221 of the 5 strike
    855 of the 6 ... 209 of the 7's and 121 of the 1 strike.

    That's a total of 15,068...They are not just going to nonchalantly let the price keep going up and let all those Options holders make money off of them..At least that hasn't been common practice for THEM..THEY ALWAYS win and take the price down to steal all the money from the open interest Call Options...

    As i said on another post, this feels like a different Geron since Jan 26,2017..A NEW GERON if you will.
    Can it withstand the assault that is surely coming from the sellers of these options who are sure to defend their position? Watch the next 3 weeks as it should be very interesting and a lot of lessons learned by all involved if THEY are able to manipulate the price down ...AGAIN...as THEY always do when there's a high count of open interest at options expiration Friday.
  • Johnson and Johnson just announced that GERN's drug is 1 of Johnson and Johnson future top revenue grossing drugs.
    GERN's drug is going full speed ahead.
    This is a great GERN buying opportunity.
  • All the day traders are out of GERN now. GERN will be higher next week after the 3 day weekend. I am buying all the GERN I can today as this is a great buying opportunity.
  • the friday sell off was on higher volume in an incredibly positive up market , so that begs the question what is seriously going on when that kind of volume THROWS AWAY THAT MANY SHARES on no news and of course we will never hear anything from the scarlett pimpernel while he continues his reign of terror on shareholders ! em
  • New short numbers out.
    33,287,790 shares short. Has not changed a bit since GERN was at 2.50. 18 days to cover.