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Incyte Corporation (INCY)

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138.54+2.38 (+1.75%)
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  • More good news for keytruda:

    May 23 (Reuters) – Merck & Co's immunotherapy Keytruda chalked up another approval on Tuesday as the U.S. Food and Drug Administration said the cancer medicine can be used to treat children and adults who carry a specific genetic feature regardless of where the disease originated.
    It is the first time the agency has approved a cancer treatment based solely on a genetic biomarker.
    "Until now, the FDA has approved cancer treatments based on where in the body the cancer started – for example, lung or breast cancers," said Richard Pazdur, head of oncology products for the FDA's Center for Drug Evaluation and Research. "We have now approved a drug based on a tumor's biomarker without regard to the tumor's original location." The accelerated approval was for solid tumor cancers not eligible for surgery or that have spread in patients identified as having a biomarker called microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR).
    Tumors with those traits are most common in colorectal, endometrial and gastrointestinal cancers, but may also appear in cancers of the breast, prostate, bladder and thyroid gland.
    The approval covers patients whose cancer has progressed despite prior treatment and those who have no satisfactory alternative treatment options. It also includes patients with colorectal cancer whose disease has advanced after chemotherapy.
    The FDA grants accelerated approvals to drugs for serious conditions with unmet medical needs if the treatment appears to have certain effects deemed reasonably likely to predict a clinical benefit. Merck must still conduct studies to confirm the anticipated benefit.
    Keytruda belongs to a new class of drugs called PD-1 or PD-L1 inhibitors that help the immune system fight cancer by blocking a mechanism tumors use to evade detection.
    It was previously approved to treat advanced melanoma, advanced non-small cell lung cancer, head and neck cancers and classical Hodgkin lymphoma.
  • Some copy-paste:

    Incyte data to 'restore positive sentiment,' says JPMorganJPMorgan analyst Cory Kasimov believes the abstracts for epacadostat demonstrate "consistent and compelling evidence" of efficacy across multiple tumor types, consistent with what Incyte has been telling the Street. The analyst is "encouraged" by emerging data and expect it will "restore positive sentiment" in the name and add to the company's perceived strategic value. He reiterates an Overweight rating on Incyte shares with a $149 price target.

    BMO Capital analyst Alex Arfaei says that "the ASCO abstracts solidify Merck's (MRK) significant leadership in the important 1L-NSCLC market." The analyst says that Incyte's (INCY) Epacadostat appears to be "adding meaningful clinical benefit to Keytruda." He believes that the data "clearly indicates" that Keytruda monotherapy should be the standard of care in about 25% of 1L-NSCLC patients.

    BMO Capital sharply raised its price target from $146 to $155

    Incyte price target lowered to $152 from $167 at Credit SuisseCredit Suisse analyst Alethia Young lowered her price target for Incyte to $152 from $167 due to moving from M&A base case valuation. While the analyst says it is possible that one day Incyte is bought, she thinks the company is progressing well in diversifying its pipeline base and de-risking its IDO inhibitor epacadostat. Young reiterates an Outperform rating on the shares.
  • A bit of let's pretend. Let's pretend the most likely outcome of the Lilly-FDA meeting happens: they agree that as soon as some statistical analyses of the ongoing extension studies and the then-completed China-directed study are furnished, a new NDA will be accepted, with answers to certain questions carried over from the prior NDA. Maybe even the equivalent of a SPA--agreement that satisfactory results in certain defined areas will be sufficient for Olumiant approval. (I still think that the sticking point now is long-term cardiovascular risks, so 6 months of extension study stand a very good chance of being "just what the doctor ordered"). Ok--a somewhat indeterminate timetable (8-12 months) to 99.9+% chance of approval. What does the stock do?

    I certainly don't expect a rapid gain as large as the loss after the CRL. I think that drop showed that even analysts who have given low sales estimates for Olumiant privately attach a decent probability to my sort of sales estimate. So it ought to generate a move comparable to what on-time approval would have generated.

    Meanwhile, actual ASCO presentations will be over ty then. The value of epac ought to be a lot better-defined by then. The base the move is taking off from ought to be more stable than the level the drop happened from. It' always possible that realistic estimates of time-to-market for epac will still be clearing stars from the eyes of analysts who were initially dazzled by phase-2 results.

    Gosh, this is complicated.
  • Do I have to say it? Knowing how intoxicated you people are and incapable of understanding the market reality, I suppose I'll have to be the responsible one and say it like it is. Remember that terrifying panic you felt when this tanked from $150 to $114? Yes, that terror. Now you remember. You have such a short memory. Did you learn your lesson about gambling on a stock with 229 P/E or are you gluttons for punishment still clinging to your delusions of a $300/share buyout, and you're going to hold till you lose everything? And please tell me you didn't buy a gambler's stock on margin. Use this opportunity to do the sane thing. Don't be the idiot crying when this hyper inflated pumper's stock tanks below $100 this year and then remembering you could have gotten out at $130.

    Be rational, don't get emotionally attached to the pumper's dream because the pumpers will be the first to sell out, just like INCY's board, and they'll leave you high and dry. In this institution controlled stock, they'll smear you like a bug and rob your nest egg and not lose a wink of sleep. To the pumpers you're just a cattle to slaughter. The pump is always the sweet poison they use to chain you to a stock. Be rational. P/E 229. All the industry leaders have a P/E around 30-40. Again... be rational not emotional.
  • 135, 134, 133, 132 131, 130, 120, 110, 100, next stop is 65
  • To the shorts: there's not a lot to say but BUY incyte, it's never to late!
  • Do not expect CEO sell out cheap. Big pharma about to make its move. Look for another 10% this week. Very dangerous stock for sure. Good luck
  • https://cc.talkpoint.com/ubsx001/052217a_as/?entity=29_X2DTMCS

    Jakafi has no rival...

    Herve very positive regarding Olumiant (Baricitinib) and said that probably not need more studies for Baricitinib, only give data from existing studies. Same info was submitted to European/US regulators. Still waiting from FDA demanding what they want ?

    Talks about epacadostat ido....

    What do you think, Doc?

  • Listened to the UBS conf. Some meta-substance on the ASCO presentations: data cut-off for the abstracts was October. Meeting presentations will include 3 more months of data. As you can well imagine, the presenters will have yet another 3 months or so to answer questions with. The go-ahead decisions at Merck and BMS were made with data in between abstract and meeting.

    HH talked as if the methodology Incyte is using to screen drug combos is useful and non-obvious...ie, patentable. That'll be amusing to watch.

    Suggestion that Lilly and FDA have had low-level conversations regarding the CRL. Unsurprising, but the substance is an obvious third rail.

    Boast that epac can be dosed as high as you please without OFF-TARGET toxicity (on-target is a matter for research).
  • Come on Tom....we know you are monitoring this MB.... still looking for $19,$18,$17... what a moron... Remember if you need a new job...Walmart needs a person to push carts in parking lot...
  • Cramer has been saying for about 18 months or more to stay away from Gilead. He's been saying, they need to put their money to work to acquire something and until they do he couldn't recommend the company. In a nut shell, stay away from this value trap until further notice. I originally questioned his judgement but, he's been correct. I'd also like to point out that it's my impression that many well respected leaders of industry (Tim Cook, etc) have granted him interviews because they seem to view him as a respectable and responsible individual. If they didn't they wouldn't give him the time of day. PS.....Incyte has existing relationships with Merck and I believe other large Pharmaceutical company's. These company's have deep pockets and the inside track regarding Incyte's oncology drugs and pipeline. Given the circumstances, I find it very unlikely that Gilead would be successful in attempting to acquire Incyte. Time will tell!
  • More reactions :

    Data reported from the biopharmaceutical company indicated that something that wasn't possible before could be possible now. Incyte has been developing a cancer immunotherapy called an IDO inhibitor. The drug maker's goal has been to use an IDO inhibitor with a PD-1 inhibitor in order to help people respond to cancer treatments better. This is compared to using just a PD-1 inhibitor. Goldman Sachs said in a note, "Solid data validates IDO as a leading IO add-on." This could be a breakthrough in medicine so no wonder traders reacted positively towards the news. Jefferies analyst Jeffrrey Holford also commented and said in a note, "INCY's IDO looks most promising in this class so far, but not very disruptive in relation to immuno-oncology as a whole."
  • Some Technical Analysis:


    Incyte ST: above its upper Bollinger band

    Comment: the RSI is above its neutrality area at 50.
    The MACD is negative and above its signal line. The MACD must break above its zero level to call for further upside.
    Moreover, the stock is trading above its 20 day MA (121.65) and above 50 day MA (132.33).
    Finally, Incyte has crossed above its upper daily Bollinger band (128.74).

    Supports and resistances:
    158.6 **
    153.2 *
    148 **
    128.8 last
    118.6 **
    110 *
    105 **
    --- TRADING CENTRAL is a commentary service specialising in technical analysis.
  • This rise in stock price brings to question whether there is information unavailable to the retail market, my guess and only a guess is we shall hear from the FDA on bari, soon
  • 170 by 4th of july
  • New ratings:

    5/18/2017 Oppenheimer Holdings Inc. Set Price Target Hold $125.00
    5/18/2017 JPMorgan Chase & Co. Set Price Target Buy $149.00
    5/19/2017 Morgan Stanley Reiterated Rating Overweight$142.00
    5/18/2017 Jefferies Group LLC Reiterated Rating Buy $148.00
  • Why Stay Bullish On Gilead
    A recent investor presentation echoed the reasons why Barclays remains bullish on this once high-flying drug maker.
    Johanna Bennett
    May 19, 2017 12:02 p.m. ET

    There’s no shortage of investors who have lost confidence in Gilead Sciences (GILD).
    Hopes of better news were shattered by its most recent earnings report. And so far, the company has not delivered a strategy for emerging from its recent melancholy.
    But Gilead’s chief operating officer, Kevin Young addressed investors at a recent conference, highlighting the outlook for the hepatitis C market, the strength of the company’s HIV drug portfolio and continued efforts to expand into new areas such as cancer and NASH.

    Add the ever-present speculation about a possible deal on the horizon, and Barclays analyst Geogff Meacham remains bullish on the drug maker with a 12-monthprice target of $85. That suggests a 33% upside for the shares.
    Gilead continues to look for the right deal (vs. just any deal), one that would provide an asset or platform capable of establishing a leadership position.  Management noted that it remains focused on the long-term, sustainable option rather than a short-term fix.
    At $64.50, Gilead's share price has fallen more than 21% over the past 12 months.

    Do they have the balls to buy incite?
  • 2nd time around, open for discussions

    Abbvie, lost humira patent, may look to replace lost sales in RA, a good plus in oncology
    Allergan, stock down alot, needs new revenue source, great tax rate, failed merger with Pfizer
    Astra Zeneca, recent fall on the clovis news, a real stretch here
    BMY, recent set back with Opdivo, shares down of late, needs to stake lead against Merck
    Gilead, Hiv sales ok, but hep c sales declining, and lots of bio similars approved, stock 4 year low
    JNJ lost out to Abbvie, on the buyout of their last partnered drug with PCYC
    Merck best bet to take the all around lead in immuno-oncology
    Novartis, Needs to sell Alcon or partnership with GSK, great potential at incyte with employees from NVS
    Pfizer, never out of the game to acquire, failed merger with Allergan, revenue is declining
    Roche, not very good news at ASCO, needs to make up ground against BMY, MRK
    Sanofi, no knowledge, but possible

    more than likely not
    Lilly, not what they do
    Abbot, just do not think they could swing a deal with Incyte
    GlaxoSmithKlein, might do a deal on partnership with Novartis
  • Now it will start the real pump machine... Like Herve said : “It’s not bad to be sexy — you want to be wanted,”

    If the data and results continue like this more deals/ties will be made. Let's make money with all key players! Love this company!

    Like Herve said: Well, we offer an open company from a partnership standpoint and we have an obsessive vision of making Incyte a company that will be one of the fastest-growing, most successful, and most profitable.
  • Incyte should go buy up the rest of AGEN