As of 05/15/2017 17,498,249 20% decline in the short interest.
$KERX 880 ims. From StockTwits
You have an FDA approved stock, you have all insurance companies approved to fund user. You have a new distribution staff in place. Sit back - this stock has takeover all over it. Go ahead and short it. Will keep buying on dips. Tired of this board writing about the ski falling. Its a biotech a takeover and it will rip your heart out shorts.
Shorty trying to scare longs out...shorty, i wouldn't sell under $20's this has take out all over it when next Q sales are $20M plus.......
Why are we stuck at 6.40. It seems someone is really trying to keep it at this price for today.
Keryx Biopharmaceuticals, Inc. (KERX) Short Interest
Keryx Biopharmaceuticals, Inc. (KERX) Short Interest � Find short interest for Keryx Biopharmaceuticals, Inc. and all the companies you research at NASDAQ.com
Not sure why everyone is happy shorts are getting off the hook....NO short squeeze to get us back to 16 sucks....they took us down and now slithering out scott free.....too bad
Auryxia should be the first binder of choice. If a patient has no serious side effects then the benefits are better than any other binder..
And salary decrease of 1000 dollars/day until there is news that makes the stock go up
short interest down by 4.5 MIL and we are in red. Difficult to understand.
Starting today, the board should subtract 5K of stock from GM every day there is NO news.....
craz, if SK is somehow involved in a potential pre-designed plan with Kerx in last years while benefitting on short side and also cashing-in on long side at conclusion, then he can take his co-ownership in horse and Red Sox and shove them where they best fit..,
Can't spend more time looking for what I just posted about why the stock price might not go up when there is a significant increase in weekly scripts. 2017 projected revenues is $64.88 million. I believe 2017 is Auryxia's third year on the market. So if large , savvy investors think revenues might be $80 million instead of $65 million, I think they would still regard the drug as a failure, especially because market share is so small, and I don't think they would invest more. 2018 revenues are supposed to be $129 million. Still not good revenues..
$KERX IMS 921.From StockTwits
From good old Doug and his parrot
$KERX Auryxia. Symphony-based TRx increased 9% and IMS-based TRx increased 7% wk/wk (704 vs. 646 and 921 vs. 862).
Seth co-owns Cloud Computing the horse that won the Preakness Saturday........Klaravich Stables.....He also is a minority owner of the Red Sox which I didn't know.......
Peter J. Enos, PharmDFollow Clinical Consultant | www.drpeterjenos.com | firstname.lastname@example.org May 16
Ferric Citrate (AURYXIA®) Drug Monograph A Comprehensive Clinical Overview of Auryxia® in a Clinical Monograph
How Supplied¹ Tablets — Auryxia 210 mg ferric iron tablets equivalent to 1 g ferric citrate are supplied as 200 tablets in 400 cc high-density polyethylene bottles. The 210 mg ferric iron tablets are film coated, peach colored, and oval-shaped tablet embossed with “KX52”. Indications¹ Control of serum phosphorus levels in patients with chronic kidney disease on dialysis. Pharmacology¹² Healthy kidneys excrete phosphate extremely efficiently, but in CKD patients, phosphate excretion becomes unpredictable As CKD progresses, PTH compensation fails in preventing phosphate reabsorption leading to supra-physiological levels of phosphate from reabsorption Upon oral administration, ferric citrate dissociates into ferric iron and citrate Ferric iron binds to several dietary phosphate ions in the GI tract and precipitates as ferric phosphate, which is excreted in the stool Auryxia ultimately reduces serum phosphate levels by preventing reabsorption Pharmacokinetics
Clinical Efficacy US Trials in Dialysis Dependent CKD² Dose-response and Efficacy of Ferric Citrate to Treat Hyperphosphatemia in Hemodialysis Patients¹²³ The study was a phase 3, multicenter, randomized, open-labeled trial comparing three fixed dosed regimens of ferric citrate. The goal of the study was to compare the clinical effectiveness of the three doses of 1g, 6 g, and 8 g ferric citrate. The results of the study concluded that ferric citrate is an effective dietary phosphate binder which reduces phosphorous levels in patients on dialysis. Ferric Citrate Controls Phosphorous and Delivers Iron in Patients on Dialysis²⁴ This study details the findings of a sequential three-period, 58-week, phase 3 randomized controlled trial. The goal of the study was to assess the safety and efficacy of ferric citrate as a phosphate binder in 441 patients with ESRD requiring dialysis. The conclusion of the study states that ferric citrate is an effective dietary phosphorous binder. It also improves ferritin and TSAT levels in addition to requiring less ESA and IV iron used in patients with CKD on dialysis. Japan Trials in Dialysis Dependent CKD Patients² A Randomized Trial of JTT-751 versus Sevelamer Hydrochloride in Patients on Hemodialysis²⁵ This study was a phase 3, multicenter, randomized, active-controlled, open-label, parallel group study. The goal of the study was to directly compare JTT-751 (ferric citrate anhydrate) and sevelamer hydrochloride in HD-dependent CKD patients. The conclusion of the study states that serum phosphate concentrations declined significantly in both groups and that intergroup difference was not significant. The study proved that JTT-751 was non-inferior to sevelamer HCl as a phosphate binder for HD-dependent CKD patients. In addition, the study also concluded that JTT-751 led to higher hemoglobin, hematocrit, serum ferritin, and TSAT than sevelamer. Long-term Safety and Efficacy of a Novel Iron-containing Phosphate Binder, JTT-751, in Patients Receiving Hemodialysis²⁶ This study was an open-label, phase 3, multicenter, dose-titration trial that recruit subjects at 29 centers in Japan. The goal of this study was to assess the safety and efficacy of JTT-751 (ferric citrate anhydrate). The conclusion of the study states that JTT-751 effectively controlled serum phosphate concentrations in patients receiving hemodialysis during a full year of study. Study also found that patients who used of JTT-751 significantly reduced IV iron use and ESA usage throughout the study. Taiwan Trials in Hemodialysis Dependent CKD² Effect of Oral Ferric Citrate on Serum Phosphorus in Hemodialysis Patients²⁷ This study was a phase 3, randomized, double blind, placebo-controlled study intended to assess the efficacy of ferric citrate as a phosphate binder in patients with ESRD on hemodialysis. The study concluded that oral ferric citrate was a safe and effective option for lowering serum phosphorous in CKD patients on hemodialysis. Contraindications/Warnings/Precautions¹² Iron overload syndromes such as hemochromatosis (excessive elevations in iron stores) Accidental overdose of iron (leading cause of fatal poisoning in children under 6 years of age) Patients with inflammatory bowel disease or active/symptomatic gastrointestinal bleeding were excluded from clinical trials. Safety not established in these patients Adverse Effects¹² May cause discolored (dark) stools, however, this staining is typical with most medications containing iron Diarrhea Nausea Constipation Vomiting Drug Interactions¹² No empirical data on avoiding drug interactions between Auryxia and most concomitant oral drugs. For oral medications where a reduction in the bioavailability of that medication would have a clinically significant effect on its safety or efficacy, consider separation of the timing of the administration between the two drugs. Separation with Auryxia depends on absorption characteristics of the medications administered concomitantly (such as time to reach peak systemic levels or whether the drug is an immediate or extended release product) Consider monitoring clinical responses or blood levels of concomitant medications that have a narrow therapeutic range
Drug/Food/Nutrient Interactions N/A Dosage Guidelines and Monitoring¹ Auryxia 210 mg ferric iron, equivalent to 1 g ferric citrate, film coated, peach colored, and oval-shaped tablet embossed with “KX52”. Pediatric Dosing: N/A¹ The safety and efficacy of Auryxia have not been established in pediatric patients Administration Options¹² Take two 1gram tablet orally 3 times per day with meals Maximum dose of 12 tablets daily Dose can be titrated at 1-week or longer intervals Monitoring parameters¹² Monitor serum phosphorous levels Titrate in decrements or increments of 1 to 2 tablets per day as needed to maintain target serum phosphorous levels Monitor for signs and symptoms of iron overload and accidental iron overdose Medication Safety Issues¹ Pregnancy Pregnancy Category B No adequate and well-controlled studies in pregnant women Overdose of iron in pregnant women may carry a risk for spontaneous abortion, gestational diabetes, and fetal malformation Labor and Delivery Effects of Auryxia on labor and delivery are unknown Nursing Mothers Data from rats have shown transfer of iron into milk by divalent metal transporter-1 (DMT-1) and ferroportin-1 (FPN-1). Possibility of infant exposure when Auryxia is administered to a nursing woman Geriatric Use Clinical study experience has not identified any obvious differences in responses between the elderly and younger patients in the tolerability or efficacy of Auryxia Overdose No data available regarding overdose of Auryxia Maximum dose studied was 12 tablets per day May lead to excessive elevations in iron stores (especially with concomitant IV iron use) Keep away from children to prevent accidental overdose Storage Store at 20°C to 25°C (68°F to 77°F) Excursions permitted to 15°C to 30°C (59°F to 86°F) Protect from moisture Cost Comparison²
Conclusion and Recommendations²⁸ Auryxia is comparable to other non-calcium based phosphate binders in terms of efficacy and price. The major advantage of Auryxia are the studies supporting the reduction in use of IV iron and ESAs. An additional study utilizing Lewis et al. trial projected a cost savings of $2,101 per patient per year with approximately $1,585 of the savings directly related from less use of ESAs. Since CKD is a chronic disease requiring regular use of IV iron and ESAs, we the study states that cost savings could continue for the entire duration of treating a CKD patient Auryxia is a safe and effective phosphate binder with limited side effects and limited drug interactions. It has the potential to reduce IV iron use and ESA usage which could potentially impact cost savings. References: Full Prescribing Information. Auryxia, ferric citrate tablets. Keryx Biopharmaceuticals, Boston, MA, 2016. Pennoyer A, Bridgeman MB. Ferric Citrate (Auryxia) for the Treatment of Hyperphosphatemia. Pharmacy and Therapeutics. 2015;40(5):329–339. Dwyer JP, Sika M, Schulman G, et al. Dose–response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. Am J Kidney Dis. 2013;61:759–766. Lewis JB, Sika M, Koury MJ, et al. Ferric citrate controls phosphorus and delivers iron in patients on dialysis. J Am Soc Nephrol. 2014;26:e1–e11. Yokoyama K, Akiba T, Fukagawa M, et al. A randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis. Nephrol Dial Transplant. 2014;29:1053–1060. Yokoyama K, Akiba T, Fukagawa M, et al. Long-term safety and efficacy of a novel iron-containing phosphate binder, JTT-751, in patients receiving hemodialysis. J Ren Nutr. 2014;24:261–267. Lee CT, Wu IW, Chiang SS, et al. Effect of oral ferric citrate on serum phosphorus in hemodialysis patients: multicenter, randomized, double-blind, placebo-controlled study. J Nephrol. 2015;28:105–113. Rodby R, Umanath K, Hsieh A, et al. Phosphorus binding with ferric citrate reduces erythropoiesis-stimulating agent (ESA) and IV iron usage and cost in patients with ESRD [abstract] Am J Kidney Dis. 2014;63:B95.
May, 19 3.10 pm user_1234 $KERX Shares available short on Fidelity 2,502,683
Market loves the new script numbers. Stock up 2 cents!