U.S. Markets open in 5 hrs 25 mins

AbbVie (ABBV) Acquires Mavupharma to Boost Cancer Portfolio

Zacks Equity Research

AbbVie Inc. ABBV announced that it has acquired Seattle-based, privately held company Mavupharma to develop novel treatments for cancer using the latter’s STING signaling pathway. The acquisition is expected to enhance AbbVie’s early-stage oncology pipeline. Financial terms of the deal have been kept under wraps.

Mavupharma's lead candidate, MAVU-104, is an orally active, small molecule that inhibits an enzyme involved in the regulation of the STING pathway known as ENPP1.

Shares of AbbVie have declined 23.7% so far this year, underperforming the industry’s decrease of 1.5%.

Oncology is a key therapeutic area for AbbVie and the company believes that it will be its major driver over the next 10 years. Key drugs in its oncology portfolio are Imbruvica, currently approved for quite a few indications and marketed in partnership with J&J JNJ, and Venclyxto/Venclexta, approved to treat chronic lymphocytic leukemia (CLL) and marketed in partnership with Roche RHHBY.

Several studies on Imbruvica are underway to evaluate the drug alone or in combination across different patient segments. AbbVie is also studying Venclyxto/Venclexta to expand its label to address a broader relapsed/refractory CLL patient population, extend into earlier lines of therapy and cover other hematologic malignancies like multiple myeloma and acute myeloid leukemia (AML).

Notably, other companies are also exploring opportunities to develop novel therapies using the STING activator platform. For instance, AduroBioTech ADRO has an exclusive collaboration and license agreement with pharma giant Eli Lilly to develop novel immunotherapies for autoimmune and other inflammatory diseases by leveraging its cGAS-STING inhibitor platform.

Further, Aduro has a collaboration and license deal with Novartis for developing and commercializing STING activator candidates in its oncology pipeline.

Zacks Rank

AbbVie currently carries a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

Radical New Technology Creates $12.3 Trillion Opportunity

Imagine buying Microsoft stock in the early days of personal computers… or Motorola after it released the world’s first cell phone. These technologies changed our lives and created massive profits for investors.

Today, we’re on the brink of the next quantum leap in technology. 7 innovative companies are leading this “4th Industrial Revolution” - and early investors stand to earn the biggest profits.

See the 7 breakthrough stocks now>>

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report
AbbVie Inc. (ABBV) : Free Stock Analysis Report
Roche Holding AG (RHHBY) : Free Stock Analysis Report
Johnson & Johnson (JNJ) : Free Stock Analysis Report
Aduro Biotech, Inc. (ADRO) : Free Stock Analysis Report
To read this article on Zacks.com click here.
Zacks Investment Research