Amgen Touts Early Lumakras Combo Data In KRAS Cancer Settings
BMO Capital Markets says that while Amgen Inc's (NASDAQ: AMGN) Lumakras (sotorasib) + PD1i data was delayed to the August 7 presentation, it did get data on the Lumakras + SHP2 inhibitor combination.
"While these data (n=21) showed clinical activity and safety, additional data could validate whether the combination can tackle "adaptive resistance," the next challenge in KRAS-targeted therapy," BMO said.
The Lumakras + SHP2 inhibitor combo showed clinical activity, but additional data will be needed to get comfortable with a meaningful benefit.
3/4 KRASi-naive patients had a partial response, and 4 had disease control. 5/6 colorectal cancer patients achieved disease control, with one patient achieving a 26% reduction in tumor burden.
The combo was well tolerated, with no Grade 4 treatment-related adverse events and 6 Grade 3 TRAEs, three leading to discontinuation.
Data in August will be compared to Mirati Therapeutics Inc's (NASDAQ: MRTX) initial front-line data from early June, which showed a high ORR (77%) in patients with a PD-L1 of TPS ≥50%, and 50% in those with a TPS 1-49%. The median duration of treatment was at only 2.1 months.
Price Action: AMGN shares are up 0.20% at $247.47 during the market session on the last check Wednesday.
Latest Ratings for AMGN
Date | Firm | Action | From | To |
|---|---|---|---|---|
Feb 2022 | Morgan Stanley | Maintains | Equal-Weight | |
Feb 2022 | Wells Fargo | Maintains | Equal-Weight | |
Feb 2022 | Barclays | Maintains | Equal-Weight |
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