The analyst says that the company is confident that the recent APOLLO-B validates the therapeutic hypothesis.
Subgroup analysis at the Heart Failure Society of America (HFSA) next week will be limited by a small number, but ALNY sees an approvable drug.
The base business continues to perform, and POC for Alzheimer's and gout is later this year.
RBC remains a buyer, noting one of the few commercially validated platforms in Biotech and prior transactions in the space.
Citi analyst says APOLLO-B data reported thus far suggests Onpattro is approvable for ATTR-CM and could potentially improve upon Pfizer Inc's (NYSE: PFE) tafamidis for cardiac outcomes.
Most importantly, data at HFSA might offer a glimpse into the potential of Onpattro's follow-up, Amvuttra, which has quarterly (potentially biannual) dosing and is likely to drive Alnylam's ATTR franchise.
Earlier today, the European Commission approved Amvuttra (vutrisiran) for hereditary transthyretin-mediated (hATTR) amyloidosis in adult patients with stage 1 or stage 2 polyneuropathy.
Price Action: ALNY shares are down 2.32% at $210.98 on the last check Tuesday.
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