U.S. markets close in 2 hours 38 minutes
  • S&P 500

    4,161.03
    -24.44 (-0.58%)
     
  • Dow 30

    34,037.70
    -162.97 (-0.48%)
     
  • Nasdaq

    13,896.83
    -155.51 (-1.11%)
     
  • Russell 2000

    2,225.93
    -36.74 (-1.62%)
     
  • Crude Oil

    63.38
    +0.25 (+0.40%)
     
  • Gold

    1,771.40
    -8.80 (-0.49%)
     
  • Silver

    25.82
    -0.28 (-1.09%)
     
  • EUR/USD

    1.2042
    +0.0062 (+0.52%)
     
  • 10-Yr Bond

    1.5920
    +0.0190 (+1.21%)
     
  • GBP/USD

    1.3990
    +0.0150 (+1.08%)
     
  • USD/JPY

    108.0770
    -0.7060 (-0.65%)
     
  • BTC-USD

    55,375.27
    -508.27 (-0.91%)
     
  • CMC Crypto 200

    1,247.01
    -51.95 (-4.00%)
     
  • FTSE 100

    7,000.08
    -19.45 (-0.28%)
     
  • Nikkei 225

    29,685.37
    +2.00 (+0.01%)
     

Arcturus' (ARCT) Shares Fall on COVID-19 Vaccine Study Results

  • Oops!
    Something went wrong.
    Please try again later.
Zacks Equity Research
·3 min read
  • Oops!
    Something went wrong.
    Please try again later.

Shares of Arcturus Therapeutics Holdings Inc. ARCT fell 54.2% after it released not so encouraging data from its phase I/II and preclinical study on its coronavirus vaccine candidate, ARCT-021. The company also announced that it received approval from the Singapore Health Sciences Authority to proceed with a phase II study of ARCT-021. However, shares of Arcturus have surged 289.7% year to date compared with the industry’s growth of 7.4%.

 

The phase I/II study results, together with preclinical data, indicated that ARCT-021 led to a potent immune response to SARS-CoV-2 and demonstrated a differentiated biological profile, whereby the immune response increased in the weeks following the vaccination. The preclinical data also showed that ARCT-021 resulted in highly potent cellular immunity to the virus. However, investors were disappointed as ARCT-021produced fewer neutralizing antibodies than expected.

Nevertheless, the phase I/II data demonstrated favorable tolerability.Immunogenicity was observed in 100% (44/44) of vaccinated subjects receiving 7.5 µg single dose & 5 µg single and prime-boost regimens.

In humoral immunodeficient animals depleted of B cells, ARCT-021 demonstrated protection with a single low-dose administration, further emphasizing the potential importance of the vaccine’s cellular immunity.

ARCT-021 (both single administration and prime-boost regimens)issignificantly effective in a primate challenge model. 

The company advanced ARCT-021 to a phase II study based on its phase I/II data. The phase II study will enable the selection of the optimal ARCT-021 vaccination regimen for phase III registrational studies. The company expects to obtain interim phase II data in early 2021, providing support for the anticipated initiation of a global phase III study in the second quarter of 2021.

We note that Pfizer Inc. PFE and BioNTech’s BNTX mRNA-based coronavirus vaccine candidate, BNT162b2, was granted emergency use authorization (EUA) by the FDA on Dec 11. Thevaccine is now approved for emergency/temporaryuse in more than 40 countries including the United Kingdom, Bahrain, Mexico, Singapore, Switzerland and Canada. Moderna’s MRNA coronavirus vaccine, mRNA-1273, has also been approved for emergency use in the United States and Canada.

Arcturus currently carries a Zacks Rank #4 (Sell).

You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

Moderna, Inc. Price

Moderna, Inc. Price
Moderna, Inc. Price

Moderna, Inc. price | Moderna, Inc. Quote

The Hottest Tech Mega-Trend of All

Last year, it generated $24 billion in global revenues. By 2020, it's predicted to blast through the roof to $77.6 billion. Famed investor Mark Cuban says it will produce "the world's first trillionaires," but that should still leave plenty of money for regular investors who make the right trades early.

See Zacks' 3 Best Stocks to Play This Trend >>


Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report
 
Pfizer Inc. (PFE) : Free Stock Analysis Report
 
Moderna, Inc. (MRNA) : Free Stock Analysis Report
 
Alcobra Ltd. (ARCT) : Free Stock Analysis Report
 
BioNTech SE Sponsored ADR (BNTX) : Free Stock Analysis Report
 
To read this article on Zacks.com click here.
 
Zacks Investment Research