SAN DIEGO, May 17, 2018 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (LIFE), a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways, today announced a poster presentation at the American Thoracic Society (ATS) International Conference to be held from May 18 – 23, 2018 in San Diego, CA. The presentation discusses the preclinical characterization of ATYR1923 as an immuno-modulatory therapeutic candidate with potentially broad therapeutic application in interstitial lung diseases.
“We are excited to present a thorough summary of our preclinical work from our ATYR1923 program, specifically as it relates to potential activity in interstitial lung diseases at the ATS International Conference in San Diego next week,” commented David King, Ph.D., Chief Scientific Officer of aTyr. “In addition, we recently completed enrollment in our ongoing Phase 1 healthy volunteer study with ATYR1923, dosing 36 subjects across six cohorts at dose levels up to 5 mg/kg. We expect to announce top-line results including pharmacokinetic and safety data from this study next month.”
Poster Presentation: Sunday May 20, 2018 from 9:15 – 11:15 AM (CDT)
Title: “Preclinical Characterization of ATYR1923 (iMod.Fc), an Immune-Modulatory Therapeutic with Potentially Broad Application in Interstitial Lung Diseases”
Presenter: Kathleen Ogilvie, Ph.D., aTyr Pharma, Inc.
- ATYR1923 has been engineered to have a long duration of action and is efficacious in bleomycin-induced lung fibrosis preclinical models when administered weekly.
- Data demonstrates that ATYR1923 dosing results in improved lung function and reduced inflammation after bleomycin induced lung injury in rats.
- Pharmacokinetic data in rats and nonhuman primates predict once monthly dosing in patients.
- Favorable safety profile observed from one- and three-month GLP toxicity studies in rats and nonhuman primates at weekly doses up to 60mg/kg with no observed adverse effects.
- Based on the preclinical data, a Phase 1 first–in-human clinical study was initiated.
About aTyr Pharma
aTyr is a clinical-stage biotechnology company engaged in the discovery and clinical development of innovative medicines using its knowledge of tRNA synthetase biology. The company is focused on the therapeutic translation of the Resokine pathway, comprised of extracellular proteins derived from the histidyl tRNA synthetase (HARS) gene family. aTyr’s clinical stage ATYR1923 candidate augments the Resokine pathway and is designed to temper immune engagement in interstitial lung diseases. aTyr’s immuno-oncology research program, targets the Resokine pathway using antibodies to enhance the immune response in tumor settings. aTyr has built an intellectual property estate, to protect its pipeline, comprising over 250 issued patents or allowed patent applications that are owned or exclusively licensed, including over 300 potential protein compositions derived from tRNA synthetase genes. For more information, please visit http://www.atyrpharma.com.
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Sr. Director, Investor Relations