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BeyondSpring's Lead Cancer Drug Protects Bone Marrow Stem Cells Within 24 Hours

  • BeyondSpring Inc (NASDAQ: BYSIannounced data from a poster presentation at the ESMO Congress 2022, including a new analysis from the Phase 2/3 PROTECTIVE-1 and PROTECTIVE-2 trials of plinabulin.

  • Plinabulin, the company's lead asset, is a selective immunomodulating microtubule-binding agent, a potent antigen-presenting cell (APC) inducer being developed as an anticancer agent.

  • Related: BeyondSpring Presents New Data From Lead Asset On Neutropenia In Multiple Myeloma Patients.

  • The data provides evidence of protection of bone marrow granulocyte-monocyte progenitor (GMP) stem cells within 24 hours after chemotherapy based on an evaluation of peripheral immature and mature neutrophil counts.

  • The absolute neutrophil count (ANC) with and without plinabulin was comparable at pre-dose C1D1 (p=0.96) but was significantly higher at 24 hours post-chemo dose with plinabulin vs. control.

  • At 24 hours post-chemo dose, the mean ANC had increased by 3.2 x 109/L with plinabulin, whereas the mean ANC had decreased by 0.55 x 109/L with the control due to the myelosuppressive effect of TAC chemotherapy.

  • Price Action: BYSI shares are down 0.47% at $1.52 on the last check Tuesday.

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