LONDON, UK / ACCESSWIRE / January 08, 2018 / Active-Investors.com has just released a free research report on Zafgen Inc. (NASDAQ: ZFGN). If you want access to this report all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=ZFGN as the Company's latest news hit the wire. On January 05, 2018, the biopharmaceutical Company that uses its expertise in MetAP2 systems biology to develop novel therapies for patients affected by a range of complex metabolic diseases, reported clinical progress for its lead product ZGN-1061 program. Moreover, the Company also announced its plans of returning to the rare metabolic disease space in 2018. It intends to develop its highly optimized MetAP2 development candidate, ZGN-1258, which is designed to treat patients suffering from Prader-Willi syndrome (PWS). Register today and get access to over 1000 Free Research Reports by joining our site below:
Active-Investors.com is focused on giving you timely information and the inside line on companies that matter to you. This morning, Zafgen most recent news is on our radar and our team decided to put out a fantastic report on the company that is now available for free below:
New Development Candidates to be Better than the First MetAP2 Inhibitor
Zafgen has taken several efforts to develop its MetAP2 pathway to enhance the profile of its new development candidates to show an increased understanding. Each of its current development candidates has been designed to specially distribute to specific target tissue systems, directly relating to the indication being pursued. Besides, these also aim to considerably reduce the exposure to other tissue systems reached by its first MetAP2 inhibitor. Given these improvements, the Company believes that the current development candidates will have a significant safety advantage over its first MetAP2 inhibitor.
Over the years, Zafgen has developed deep proprietary knowledge of MetAP2 systems biology. Alongside, it has improved the translation of this biology with new insights, chemistries and product candidates, which will provide safer and more effective treatment options for patients affected by a range of serious, metabolically driven conditions. The Company aims to advance these programs further in 2018 to drive shareholder value and eventually deliver potentially transformative therapies to patients in need.
Update About Zafgen's Key Programs
ZGN-1061 for Type-2 Diabetes
- ZGN-1061 is Zafgen's investigational MetAP2 inhibitor, which has been specifically developed for the treatment of Type-2 diabetes.
- The Company shared that it has completed enrollment for ZGN-1061 Phase-2 clinical trial of ZGN-1061. In fact, it received participation of 137 patients compared to the initial plan of 120 patients, i.e. 14% higher than planned. Zafgen noted accelerated participation interest in the final weeks of the enrollment period. The Phase-2 trial is designed to assess the safety, tolerability, and glucose-lowering efficacy of ZGN-1061 in diabetes patients who are also obese. The top-line data from the Phase-2 Trial is expected by the mid of 2018.
ZGN-1258 for Prader-Willi Syndrome and Additional Rare Disorders
- Prader-Willi syndrome is a genetic disorder that causes obesity, intellectual disability, and shortness in height. It is basically a rare form of life-threatening obesity, which is characterized by relentless pathologic hunger (i.e. hyperphagia) leading to dangerous food-seeking behavior.
- Zafgen has chosen ZGN-1258 as its development candidate for treating rare or orphan metabolic diseases, such as PWS, after extensive optimization and preclinical safety and efficacy profiling. ZGN-1258 is designed to alter the way the body metabolizes fat, reduces fat mass, and decreases hyperphagia in PWS.
- In fact, ZGN-1258 shows an improved ability to act on hunger control centers, over and above peripheral adipose tissue, which differentiates it from ZGN-1061. As per preclinical studies, the efficacy profile of ZGN-1258 closely aligns with the data from Zafgen's first MetAP2 inhibitor. However, the new compound has no activity in endothelial cells in vitro, which is very important in reducing the risk of thrombosis and thrombotic events in this patient population.
- The Company proclaimed that it would initiate investigational new drug (IND) application-enabling work in preparation for filing an IND with the US Food and Drug Administration (FDA) in the first quarter of 2018. It also intends to commence its Phase-1 clinical development by the end of the year.
- Moreover, Zafgen also intends to develop a global PWS natural history study mid-year as part of its commitment to the PWS community. This study would elaborate on Zafgen's development program and offer first-ever insights into the medical and clinical history of people with PWS.
Sufficient Cash Resources
Zafgen also highlighted an improvement in its cash position during Q4 2017. The Company revealed that it would end calendar year 2017 with approximately $100 million in cash, cash equivalents, and marketable securities. Therefore, Zafgen seems to be well capitalized to fund its clinical-stage development programs beyond the first half of 2019. The Company expects to achieve multiple data readouts and other program milestones in that period.
New Debt Financing Agreement
Zafgen entered into a venture debt financing agreement with Silicon Valley Bank worth $20 million on December 29, 2017. This added non-dilutive capital to its balance sheet, delaying its expected cash runway beyond the first half of 2019.
Stock Performance Snapshot
January 05, 2018 - At Friday's closing bell, Zafgen's stock rose 8.19%, ending the trading session at $5.55.
Volume traded for the day: 538.02 thousand shares, which was above the 3-month average volume of 109.04 thousand shares.
Stock performance in the last month – up 44.16%; previous three-month period – up 65.67%; past twelve-month period – up 65.67%; and year-to-date - up 20.13%
After last Friday's close, Zafgen's market cap was at $156.90 million.
The stock is part of the Healthcare sector, categorized under the Biotechnology industry. This sector was up 0.9% at the end of the session.
Active-Investors (A-I) produces regular sponsored and non-sponsored reports, articles, stock market blogs, and popular investment newsletters covering equities listed on NYSE and NASDAQ and Canadian stocks. A-I has two distinct and independent departments. One department produces non-sponsored analyst certified content generally in the form of press releases, articles and reports covering equities listed on NYSE and NASDAQ and the other produces sponsored content (in most cases not reviewed by a registered analyst), which typically consists of compensated investment newsletters, articles, and reports covering listed stocks and micro-caps. Such sponsored content is outside the scope of procedures detailed below.
A-I has not been compensated; directly or indirectly; for producing or publishing this document.
PRESS RELEASE PROCEDURES:
The non-sponsored content contained herein has been prepared by a writer (the "Author") and is fact checked and reviewed by a third-party research service company (the "Reviewer") represented by a credentialed financial analyst [for further information on analyst credentials, please email email@example.com. Rohit Tuli, a CFA® charter-holder (the "Sponsor"), provides necessary guidance in preparing the document templates. The Reviewer has reviewed and revised the content, as necessary, based on publicly available information which is believed to be reliable. Content is researched, written and reviewed on a reasonable effort basis. The Reviewer has not performed any independent investigations or forensic audits to validate the information herein. The Reviewer has only independently reviewed the information provided by the Author according to the procedures outlined by A-I. A-I is not entitled to veto or interfere in the application of such procedures by the third-party research service company to the articles, documents or reports, as the case may be. Unless otherwise noted, any content outside of this document has no association with the Author or the Reviewer in any way.
A-I, the Author, and the Reviewer are not responsible for any error which may be occasioned at the time of printing of this document or any error, mistake or shortcoming. No liability is accepted whatsoever for any direct, indirect or consequential loss arising from the use of this document. A-I, the Author, and the Reviewer expressly disclaim any fiduciary responsibility or liability for any consequences, financial or otherwise arising from any reliance placed on the information in this document. Additionally, A-I, the Author, and the Reviewer do not (1) guarantee the accuracy, timeliness, completeness or correct sequencing of the information, or (2) warrant any results from use of the information. The included information is subject to change without notice.
NOT AN OFFERING
This document is not intended as an offering, recommendation, or a solicitation of an offer to buy or sell the securities mentioned or discussed, and is to be used for informational purposes only. Please read all associated disclosures and disclaimers in full before investing. Neither A-I nor any party affiliated with us is a registered investment adviser or broker-dealer with any agency or in any jurisdiction whatsoever. To download our report(s), read our disclosures, or for more information, visit http://active-investors.com/legal-disclaimer/.
For any questions, inquiries, or comments reach out to us directly. If you're a company we are covering and wish to no longer feature on our coverage list contact us via email and/or phone between 09:30 EDT to 16:00 EDT from Monday to Friday at:
Phone number: 73 29 92 6381
Office Address: 6, Jalan Kia Peng, Kuala Lumpur, 50450 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
CFA® and Chartered Financial Analyst® are registered trademarks owned by CFA Institute.