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Blog Exposure - Zai Lab Inks Exclusive License Deal with Entasis for ETX2514 in the Asia/Pacific Region

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LONDON, UK / ACCESSWIRE / April 27, 2018 / Active-Investors.com has just released a free research report on Zai Lab Ltd (NASDAQ: ZLAB). If you want access to this report all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=ZLAB as the Company's latest news hit the wire. On April 25, 2018, the Company announced that it has inked an exclusive license agreement with Entasis Therapeutics Holdings Inc. ("Entasis") for the rights to ETX2514, which is a novel broad-spectrum intravenous inhibitor of β-lactamases, in the Asia/Pacific region. Register today and get access to over 1000 Free Research Reports by joining our site below:


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Global Strategic Development Collaboration

The Companies also signed a global collaboration deal for the development of ETX2514SUL, a fixed-dose combination of ETX2514 and sulbactam, for the treatment of a variety of serious multidrug-resistant infections caused by Acinetobacter baumannii. Zai Lab will manage the portion of the Phase-3 trial of ETX2514SUL conducted in China. ETX2514SUL is currently in Phase-2 development with plans to move into global Phase-3 clinical trials in Q1 2019.

Acinetobacter baumannii is a Gram-negative bacterium causing severe infections associated with high mortality, and has emerged as a cause of numerous global outbreaks, displaying ever-increasing rates of antibiotic resistance which greatly limits treatment options.

Terms of the Agreement

  • Entasis has granted Zai Lab an exclusive license to develop and commercialize ETX2514SUL in specified countries in the Asia/Pacific region, including Japan.
  • Entasis and Zai Lab will cooperate in conducting Phase-3 trial in China, with Zai Lab taking the lead by conducting the screening, enrollment, and treatment of patients, and coordinating development and registration.
  • Entasis and Zai Lab can also partner on the development and commercialization of ETX2514 in combination with other active ingredients. A joint steering committee will be formed between the Companies to oversee development, regulatory, and commercialization activities in the Asia/Pacific territory.
  • In addition to the financial support for the portion of the Phase-3 trial conducted in China, Zai Lab will make an upfront payment of $5 million to Entasis, along with an aggregate of $7.6 million in near-term development milestones, and up to an aggregate of $91.0 million in additional milestone payments related to ETX2514SUL, plus royalties.

Collaboration to Offset Costs and Enable Patients Enrollment from China into Entasis' Global Phase-3 Clinical Trial

Manos Perros, Chief Executive Officer (CEO) of Entasis, stated that the Company is happy to partner with Zai Lab on the development and commercialization of ETX2514SUL in the Asia/Pacific region, most notably in Greater China, where the rate of Acinetobacter baumannii infections rank among the highest in the world. With their experienced leadership team, focus on innovation, and established expertise and network within the infectious diseases arena, Zai Lab is the ideal partner to help bring ETX2514SUL to the numerous patients in the region who need a new effective treatment option. Perros added that the collaboration will offset costs and enable enrollment of patients from China into Entasis' global Phase-3 clinical trial, further supporting its plans to rapidly progress ETX2514SUL to market.

Zai Lab's License Deal with Five Prime Therapeutics

In December 2017, Zai Lab signed an exclusive license deal with Five Prime Therapeutics, Inc. ("Five Prime") for FPA144 in Greater China, as well as a global strategic development collaboration. Five Prime's FPA144 is a first-in-class isoform-selective, humanized monoclonal antibody in clinical development as a targeted immuno-therapy for tumors that overexpress FGFR2b, including gastric and gastro-esophageal junction cancer. The Phase-3 portion of the FIGHT trial evaluating FPA144 plus chemotherapy is expected to start in H2 2018, and would serve as a global registrational study for the treatment of front-line gastric and gastro-esophageal junction cancers. Zai Lab will manage the Phase-3 portion of the trial in China.

About ETX2514

Entasis' ETX2514 is a broad-spectrum and potent inhibitor of class A, C, and D beta-lactamases. Sulbactam is a beta-lactam antimicrobial with activity against Acinetobacter baumannii, but beta-lactamase-mediated resistance to sulbactam is now widespread. In pre-clinical studies, ETX2514 restores sulbactam's antimicrobial activity. Entasis is developing the combination of sulbactam and ETX2514 for the treatment of drug-resistant Acinetobacter baumannii infections. A Phase-1 trial of ETX2514SUL has been recently completed with positive results for pharmacokinetics and drug toleration.

About Entasis Therapeutics Holdings Inc.

Entasis is a clinical-stage biopharmaceutical organization focused on the discovery, development, and commercialization of novel antibacterial products to treat serious infections caused by multidrug-resistant Gram-negative bacteria. The Company was formed in 2015 and is based in Waltham, Massachusetts.

About Zai Lab Ltd

Established in 2014 and headquartered in Shanghai, China, Zai Lab is an innovative biopharmaceutical organization focused on bringing transformative medicines for cancer, autoimmune, and infectious diseases. The Company has offices in Beijing, manufacturing facilities at the Suzhou BioBay China Industry Park, and a satellite office in the US.

Stock Performance Snapshot

April 26, 2018 - At Thursday's closing bell, Zai Lab's stock slightly dropped 0.16%, ending the trading session at $18.41.

Volume traded for the day: 35.08 thousand shares.

After yesterday's close, Zai Lab's market cap was at $912.95 million.

The stock is part of the Healthcare sector, categorized under the Biotechnology industry. This sector was up 1.2% at the end of the session.


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