U.S. Markets closed

Blog Exposure - ZIOPHARM Updated on Key Clinical Programs and Corporate Development Activities

LONDON, UK / ACCESSWIRE / January 11, 2018 / Active-Investors.com has just released a free research report on ZIOPHARM Oncology, Inc. (NASDAQ: ZIOP). If you want access to this report all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=ZIOP as the Company's latest news hit the wire. On January 09, 2018, the Company announced that it provided an update on its important clinical programs and corporate development activities during the 36th Annual J.P. Morgan Healthcare Conference. Register today and get access to over 1000 Free Research Reports by joining our site below:

www.active-investors.com/registration-sg

Active-Investors.com is focused on giving you timely information and the inside line on companies that matter to you. This morning, ZIOPHARM Oncology most recent news is on our radar and our team decided to put out a fantastic report on the company that is now available for free below:

www.active-investors.com/registration-sg/?symbol=ZIOP

Ziopharm Implementing New Paradigm for Production of TCR with Sleeping Beauty Non-Viral Platform

Ziopharm's immunotherapies in clinical trials are based on two powerful platforms. The Company has shown that it can super-charge a patient's own immune system with controlled, local production of IL-12. It can also provide a new immune response infusing genetically modified T cells with a unique and advantageous manufacturing process. Ziopharm is implementing a new paradigm for production of genetically modified T cells with our Sleeping Beauty (SB) non-viral platform and proprietary membrane bound IL-15 which enables very rapid manufacture of CAR- and TCR-modified cells at low cost and scale.

Updates on Clinical Programs and Cell Therapies

  • Ziopharm, in partnership with Intrexon Corp., is advancing Ad-RTS-hIL-12 + veledimex, or controlled interleukin-12 (IL-12), as a gene therapy for recurrent glioblastoma (rGBM). A Phase-1 trial demonstrated the safety of controlled local expression of IL-12, which can turn cold tumors hot, which could have a profound impact for oncology.
  • The Company announced the initiation of a Phase-I clinical trial to evaluate Ad-RTS-hIL-12 + veledimex in combination with OPDIVO® (nivolumab), an immune checkpoint, or PD-1, inhibitor, in adult patients with rGBM. Ziopharm updated guidance on its planned pivotal trial and will initiate in the second half of 2018.
  • Ziopharm has designed the randomized control trial to evaluate controlled IL-12 for the treatment of patients with rGBM and following meetings with US and European regulators is completing Chemistry Manufacturing and Control technical requirements. The Company is simultaneously working on accumulating additional clinical data from the open Phase-1 trials, including the combination trial.
  • The Company, in collaboration with Intrexon and with MD Anderson Cancer Center, the National Cancer Institute (NCI) and Merck KGaA, Darmstadt, Germany, is developing chimeric antigen receptor (CAR) T cell (CAR+ T) and T-cell receptor (TCR) T cell (TCR+ T) therapies.

First Point-of-Care Clinical Trial Expected in 2018

Ziopharm is advancing its non-viral Sleeping Beauty (SB) platform towards P-O-C for the very rapid manufacturing of genetically modified CAR+ T cells, with the first clinical trial utilizing this approach. The trial is likely to begin this year. Data supporting P-O-C were presented at the 59th American Society of Hematology Annual Meeting in December 2017. The Company expects to initiate the third-generation P-O-C study, which leverages SB to manufacture CAR+ T cells co-expressing a membrane-bound interleukin-15, or mbIL15, in less than two days.

Phase-1 Study of SB-Modified TCRs to Begin in Second Half of 2018

The Company updated guidance on the anticipated start of the National Cancer Institute (NCI)-led Phase-1 trial to evaluate adoptive cell transfer (ACT)-based immunotherapies genetically modified using the SB transposon/transposase system to express TCRs for the treatment of solid tumors. In January 2017, Ziopharm, Intrexon, and the NCI signed Cooperative Research and Development Agreement for the development of ACT based immunotherapies genetically modified using the SB transposon/transposase system to express TCRs to treat patients with advanced cancers.

Phase-1 Study of CD33-Specific CAR+T therapy in AML Underway

The Company is enrolling in the Phase-1 adoptive cellular therapy clinical trial of CD33-specific CAR+ T cell therapy in patients with refractory/recurrent Acute Myeloid Leukemia (AML). The trial is enrolling at The University of Texas MD Anderson Cancer Center. The data are expected to serve as the basis for evaluating CD33 as a potential target for further development using very rapid non-viral manufacturing of T cells under P-O-C.

About ZIOPHARM Oncology, Inc.

Founded in 1998, Ziopharm Oncology, Inc. is a biopharmaceutical company focused on the discovery and development of new cancer therapies. The Company employs novel gene expression, control and cell technologies to deliver safe, effective and scalable cell-based therapies for the treatment of cancer and graft-versus-host-disease (GvHD), a type of auto-immune disease. ZIOPHARM is headquartered in Boston, Massachusetts.

Stock Performance Snapshot

January 10, 2018 - At Wednesday's closing bell, ZIOPHARM Oncology's stock marginally rose 0.61%, ending the trading session at $4.13.

Volume traded for the day: 1.11 million shares.

After yesterday's close, ZIOPHARM Oncology's market cap was at $586.29 million.

The stock is part of the Healthcare sector, categorized under the Biotechnology industry.

Active-Investors:

Active-Investors (A-I) produces regular sponsored and non-sponsored reports, articles, stock market blogs, and popular investment newsletters covering equities listed on NYSE and NASDAQ and Canadian stocks. A-I has two distinct and independent departments. One department produces non-sponsored analyst certified content generally in the form of press releases, articles and reports covering equities listed on NYSE and NASDAQ and the other produces sponsored content (in most cases not reviewed by a registered analyst), which typically consists of compensated investment newsletters, articles and reports covering listed stocks and micro-caps. Such sponsored content is outside the scope of procedures detailed below.

A-I has not been compensated; directly or indirectly; for producing or publishing this document.

PRESS RELEASE PROCEDURES:

The non-sponsored content contained herein has been prepared by a writer (the "Author") and is fact checked and reviewed by a third-party research service company (the "Reviewer") represented by a credentialed financial analyst [for further information on analyst credentials, please email info@active-investors.com. Rohit Tuli, a CFA® charter-holder (the "Sponsor"), provides necessary guidance in preparing the document templates. The Reviewer has reviewed and revised the content, as necessary, based on publicly available information which is believed to be reliable. Content is researched, written and reviewed on a reasonable effort basis. The Reviewer has not performed any independent investigations or forensic audits to validate the information herein. The Reviewer has only independently reviewed the information provided by the Author according to the procedures outlined by A-I. A-I is not entitled to veto or interfere in the application of such procedures by the third-party research service company to the articles, documents or reports, as the case may be. Unless otherwise noted, any content outside of this document has no association with the Author or the Reviewer in any way.

NO WARRANTY

A-I, the Author, and the Reviewer are not responsible for any error which may be occasioned at the time of printing of this document or any error, mistake or shortcoming. No liability is accepted whatsoever for any direct, indirect or consequential loss arising from the use of this document. A-I, the Author, and the Reviewer expressly disclaim any fiduciary responsibility or liability for any consequences, financial or otherwise arising from any reliance placed on the information in this document. Additionally, A-I, the Author, and the Reviewer do not (1) guarantee the accuracy, timeliness, completeness or correct sequencing of the information, or (2) warrant any results from use of the information. The included information is subject to change without notice.

NOT AN OFFERING

This document is not intended as an offering, recommendation, or a solicitation of an offer to buy or sell the securities mentioned or discussed, and is to be used for informational purposes only. Please read all associated disclosures and disclaimers in full before investing. Neither A-I nor any party affiliated with us is a registered investment adviser or broker-dealer with any agency or in any jurisdiction whatsoever. To download our report(s), read our disclosures, or for more information, visit http://active-investors.com/legal-disclaimer/.

CONTACT

For any questions, inquiries, or comments reach out to us directly. If you're a company we are covering and wish to no longer feature on our coverage list contact us via email and/or phone between 09:30 EDT to 16:00 EDT from Monday to Friday at:

Email: info@active-investors.com

Phone number: 73 29 92 6381

Office Address: 6, Jalan Kia Peng, Kuala Lumpur, 50450 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia

CFA® and Chartered Financial Analyst® are registered trademarks owned by CFA Institute.

SOURCE: Active-Investors

  • Puppies Found Healthy in California House of Horrors Are Up for Adoption, Officials Say
    News
    Time

    Puppies Found Healthy in California House of Horrors Are Up for Adoption, Officials Say

    A pair of puppies belonging to the Perris, Calif. couple accused of torturing and starving their 13 children are up for adoption, city officials said. The City of Perris said it is holding an adoption raffle, beginning Friday, to find a new home for two small dogs that authorities seized from David and Louise Turpin after the couple’s arrest this week. The dogs — female Maltese-mixes, each about 1-year-old — appear healthy and friendly, Perris Senior Animal Control Officer Christina Avila said in a news release.

  • Delta is cracking down on people who use fake emotional-support animals to let their pets fly for free (DAL)
    Finance
    Business Insider

    Delta is cracking down on people who use fake emotional-support animals to let their pets fly for free (DAL)

    Delta Air Lines is adopting stricter regulations for people who travel with service animals or emotional-support animals. The airline says the new rules are in response to a rise in safety incidents involving untrained or improperly trained animals. The stricter standards are designed to prevent people from using the airline's allowance of emotional-support animals to let their pets fly for free.

  • This Flu Map Shows How the Biggest Influenza Outbreak in Years Spread Across the U.S.
    Health
    Time

    This Flu Map Shows How the Biggest Influenza Outbreak in Years Spread Across the U.S.

    With months left to go in the 2018 flu season, the U.S. has already hit an unfortunate benchmark, as shown on the flu map below: For the first time in the Centers for Disease Control and Prevention’s 13 years of influenza monitoring, every state in the continental U.S. is seeing “widespread” virus activity. The U.S. is experiencing such an active flu season that the CDC held a special briefing on the topic last week, explaining that there’s an uptick in both confirmed cases of the disease and hospitalizations related to it this year. Spread of the disease was bolstered by the circulation of H3N2, an influenza strain that’s particularly aggressive and was only successfully targeted by vaccines in about 30% of cases, according to the CDC.

  • Olympic Gymnast Jordyn Wieber Says She Was Abused by Team Doctor
    Sports
    Time

    Olympic Gymnast Jordyn Wieber Says She Was Abused by Team Doctor

    Olympic gymnast Jordyn Wieber is the fourth member of the 2012 Fierce Five to accuse the national team doctor of sexual abuse. Reading a prepared statement at the sentencing hearing of Nassar in a Lansing, Mich., court, Wieber fought back tears as she delivered a six-minute statement. Wieber said she began seeing Nassar at age eight, since she grew up in Lansing and Nassar worked at nearby Michigan State University.

  • The Internet Is Overwhelmed With Feelings About Prince William's Freshly Shorn Head
    Celebrity
    Time

    The Internet Is Overwhelmed With Feelings About Prince William's Freshly Shorn Head

    Watch Entertainment Tonight on Yahoo View. While plenty of people have been busy paying attention to Meghan Markle’s artfully mussed low chignon, another royal’s new hairstyle — or rather, the lack thereof — made its debut. Prince William showed off

  • Steve Wozniak is still on Apple's payroll four decades after co-founding the company
    Business
    CNBC

    Steve Wozniak is still on Apple's payroll four decades after co-founding the company

    Apple (NASDAQ: AAPL) co-founder Steve Wozniak made a surprising revelation on Wednesday evening to an audience in Silicon Valley. "I'm still technically an employee," Wozniak said, during a panel discussion at the Computer History Museum in Mountain View, California. Speaking in front of about 500 people, including former employees of Hewlett-Packard and Intel (NASDAQ: INTC), Wozniak told moderator Michael Malone that "it's a small paycheck" compared to what he once earned as an executive.

  • 'Star Wars: The Last Jedi' Yanked From Chinese Theaters
    Entertainment
    Fortune

    'Star Wars: The Last Jedi' Yanked From Chinese Theaters

    The Force isn’t just weak in China, it’s pretty much non-existent. Star Wars: The Last Jedi has been pulled from cinemas in parts of China after tanking with audiences. In its second week, box office receipts were down a jaw dropping 92%.

  • Apple Is About to Introduce an iPhone Feature It Doesn't Want You to Use
    Business
    Fortune

    Apple Is About to Introduce an iPhone Feature It Doesn't Want You to Use

    Apple will allow iPhone users to switch off the performance reductions that the company has introduced in the last year to counteract the effects of ageing batteries, Tim Cook has said. Cook’s comments came in a Wednesday ABC interview that largely dealt with Apple’s plans to pay $38 billion in taxes to repatriate hundreds of billions of overseas dollars—a move it attributes to the recent tax overhaul—and to recruit 20,000 workers over the next five years. The interview also delved into the battery controversy, which hit last month when it emerged that Apple aapl was artificially degrading the performance of certain older iPhone models.

  • Trump's Haitian Work Visa Ban Could Cripple Mar-a-Lago
    Politics
    Fortune

    Trump's Haitian Work Visa Ban Could Cripple Mar-a-Lago

    The Trump administration’s decision to exclude Haitians from receiving temporary agricultural and seasonal visas in the U.S. could work against the interests of the Trump Organization. An announcement from the Department of Homeland Security (DHS)

  • Rep. Hoyer Says Trump Is 'Dead, Flat Wrong' for Saying Democrats Would Cause Shutdown
    Politics
    Bloomberg Video

    Rep. Hoyer Says Trump Is 'Dead, Flat Wrong' for Saying Democrats Would Cause Shutdown

    Jan.19 -- Rep. Steny Hoyer, a Maryland Democrat, talks about the possibility of a government shutdown and the need for immigration reform. He speaks with Bloomberg's Kevin Cirilli.

  • 'I Feel Horrible.' Former University of Alabama Student Apologies After Using Racial Slur in Video
    News
    Time

    'I Feel Horrible.' Former University of Alabama Student Apologies After Using Racial Slur in Video

    A former student at the University of Alabama has apologized after posting videos to social media in which she used the N-word repeatedly. Harley Barber, who identified herself as a member of the Alpha Phi sorority on Instagram, said Wednesday in an interview with the New York Post that she was expelled from the school following the incident. While university officials did not confirm whether Barber was expelled, a spokesperson told the Associated Press that she is no longer enrolled at the college.

  • An Asteroid Bigger Than the World's Tallest Building Will Fly by Earth Next Month
    Science
    Time

    An Asteroid Bigger Than the World's Tallest Building Will Fly by Earth Next Month

    A massive “potentially hazardous” asteroid spanning more than the length of the world’s tallest building will fly by our planet on Feb. 4. The roughly .7-mile long asteroid is considered longer than the Burj Khalifa, which at .5 miles high currently stands as the world’s tallest building, and will fly at a speed of 67,000 miles per hour just 2.6 million miles from Earth. “This is a fairly routine close approach of an object that we have known about for many years,” said Paul Chodas who manages the Center for Near Earth Object Studies at NASA’s Jet Propulsion Laboratory. Asteroid 2002 AJ192 was discovered in 2002.

  • Burger King Takes on McDonald’s With New Double Quarter Pound Sandwich
    Business
    Fortune

    Burger King Takes on McDonald’s With New Double Quarter Pound Sandwich

    Burger King is launching a new Double Quarter Pound King Sandwich today, a new burger containing a half-pound of beef topped with American cheese, pickles, sliced onions, and ketchup on a toasted sesame seed bun, reports USA Today. It contains 60% more meat than was included in the previous Big King burger. Burger King is putting McDonald's straight in its crosshairs with the new burger.

  • Jack Welch having meltdown amid GE woes: Sources
    Business
    Fox Business Videos

    Jack Welch having meltdown amid GE woes: Sources

    Sources tell FOX Business’ Charlie Gasparino that former General Electric Chairman and CEO Jack Welch is said to be apoplectic over the company’s problems as shares drop.

  • OPEC Frets About Flood of U.S. Shale
    Business
    Bloomberg

    OPEC Frets About Flood of U.S. Shale

    OPEC increased its forecast for rival oil-supply growth for a second month running after a recovery in prices sent Brent crude to $70 a barrel. OPEC’s output cuts -- now entering a second year -- have been successful in eroding bloated stockpiles and lifting prices to a three-year high. Yet the rally has prompted concern that competitors in the U.S. will be emboldened to expand production. “Higher oil prices are bringing more supply to the market, particularly in North America,” the Organization of Petroleum Exporting Countries said Thursday in its monthly report. The group raised its forecast for 2018 non-OPEC supply growth by 160,000 barrels a day, or 16 percent, to 1.15 million barrels a day.

  • This High-Yield Stock Just Declared Its 95th Dividend Increase
    Business
    Motley Fool

    This High-Yield Stock Just Declared Its 95th Dividend Increase

    Net-lease REIT Realty Income Corporation (NYSE: O) recently announced a 4% dividend increase, which represents the 95th time the payout has been raised since the company's 1994 NYSE listing. As I mentioned, Realty Income just announced its 95th dividend increase since listing on the NYSE in 1994. The monthly dividends, of which Realty Income will have paid 571 in a row, are going up by 4% from $0.2125 to $0.219 ($2.628 annualized).

  • Delta Air to tighten rules for onboard service animals
    News
    Reuters

    Delta Air to tighten rules for onboard service animals

    Delta Air Lines is tightening the requirements for passengers traveling with onboard service and emotional support animals, the carrier said on Friday, following a sharp uptick in pet-related safety issues in recent years. Effective March 1, Delta, the second largest U.S. airline by passenger traffic, said it will require passengers seeking to fly with pets to present additional documents outlining the passenger's need for the animal and proof of its training and vaccinations, 48 hours prior to the flight. This comes in response to what the carrier said was a 150 percent increase in service and support animals - pets, often dogs, that accompany people with disabilities - carried onboard since 2015.

  • The end of bitcoin
    Business
    The Week

    The end of bitcoin

    The bitcoin boom may be over. And the death of the cryptocurrency craze may well come at the hands of government regulators. Earlier this week, Bloomberg reported that Chinese authorities plan to block domestic access to central cryptocurrency trading platforms and related services. Subsequent stories suggested officials in Russia and South Korea might pull similar moves. In response, the price of a single bitcoin — the world's premiere digital currency — has plummeted. Over the weekend, bitcoins were valued at nearly $14,500. That price tag plunged below $9,500 on Wednesday, before bouncing back Thursday — though still only to $12,000. Worse still, bitcoin has been on a slow slide since December,

  • Wrong on GE, market-beating value investor Bill Nygren says he is sticking by tanking blue chip
    Business
    CNBC.com

    Wrong on GE, market-beating value investor Bill Nygren says he is sticking by tanking blue chip

    Oakmark's Bill Nygren shared his market views and top stock ideas in an interview Thursday on CNBC's "Halftime Report." General Electric was "the worst performing stock in our portfolio. We were seriously off," he said. However, he added his fund is sticking with its position and expressed confidence in the industrial company's new management team. "In this case, there has been a tremendous change in people," the investor said. "We think [their businesses] deserve better than average multiples. We think with a fresh look GE deserves to be in the portfolio." John Flannery succeeded Jeff Immelt as General Electric's CEO in August. Nygren said his fund owns more shares of General Electric after

  • There’s Been A Massive Shift To The Right In The Immigration Debate
    Politics
    FiveThirtyEight

    There’s Been A Massive Shift To The Right In The Immigration Debate

    President Trump’s disparaging comments in an Oval Office meeting last week about Haiti and “shithole” (or “shithouse”) African countries felt like the immigration debate had reached a new place. It has — but not just because of that meeting. There’s been a massive conservative shift in the ongoing debate over immigration. With Republicans in control of the White House and Congress, and some of the party pushing a hard anti-immigrant stance, Democrats and immigration advocates have had to greatly temper their hopes for reform. The last big effort at immigration reform came five years ago, in a bill written by a bipartisan group of senators known as the Gang of Eight. It included a path to citizenship

  • Why It’s a Big Deal That USA Gymnastics Is Cutting Ties With the Karolyi Ranch
    Sports
    Time

    Why It’s a Big Deal That USA Gymnastics Is Cutting Ties With the Karolyi Ranch

    In a statement Thursday, USA Gymnastics president and CEO Kerry Perry said the organization will no longer use the Karolyi Ranch as the national team training center. USA Gymnastics has terminated its agreement with the Karolyi Ranch in Huntsville, Texas. Since the 1990s, the ranch has hosted monthly training camps for elite level gymnasts — the world and Olympic women’s teams train there before competitions and for aspiring gymnasts, an invitation to the camp was the first step toward becoming a champion.

  • Rex Tillerson Says There Is Evidence That Sanctions Are 'Really Starting to Hurt' North Korea
    World
    Time

    Rex Tillerson Says There Is Evidence That Sanctions Are 'Really Starting to Hurt' North Korea

    U.S. Secretary of State Rex Tillerson said on Wednesday the United States is getting evidence that international sanctions are “really starting to hurt” North Korea, even as he accused Russia of not implementing all of the measures. U.S. President Donald Trump told Reuters in an interview earlier on Wednesday that Russia was helping North Korea evade international sanctions and that Pyongyang was getting closer every day to being able to deliver a long-range missile to the United States.

  • Prosecutors Lay Out Horrifying Details in 'Severe, Pervasive, Prolonged' Torture of 12 Siblings
    News
    Time

    Prosecutors Lay Out Horrifying Details in 'Severe, Pervasive, Prolonged' Torture of 12 Siblings

    Prosecutors laid out horrifying details of the allegations but didn’t offer any theories about the motivation for what they called an escalating climate of brutality that began in Texas and ended in a small, close-knit desert town a couple of hours southeast of Los Angeles. “The victimization appeared to intensify over time,” Riverside County District Attorney Mike Hestrin said. David Turpin, 56, and Louise Turpin, 49, pleaded not guilty Thursday to multiple counts of torture, child abuse, dependent adult abuse and false imprisonment.

  • The Latest: Trump sees 'progress' as shutdown approaches
    Politics
    Associated Press

    The Latest: Trump sees 'progress' as shutdown approaches

    President Donald Trump is striking an optimistic tone as the deadline for a federal government shutdown nears. Trump tweeted Friday afternoon, less than seven hours before the midnight deadline, that he had "an excellent preliminary meeting" in the Oval Office with Senate Minority Leader Chuck Schumer. Schumer told reporters after the White House meeting that progress had been made but a deal had not yet been reached.

  • Finance
    24/7 Wall St.

    Why Schlumberger Q4 Earnings Disappointed Investors

    Schlumberger Ltd. (SLB) reported fourth-quarter and full-year 2017 results before markets opened on Friday. The oil field services firm reported adjusted diluted quarterly earnings per share (EPS) of $0.48 on revenues of $8.18 billion. In the same period