- First preclinical data for newly-announced IL4I1 immuno-oncology program
- Preclinical data for orally bioavailable CD73 inhibitor CB-708
SOUTH SAN FRANCISCO, Calif., Oct. 01, 2019 (GLOBE NEWSWIRE) -- Calithera Biosciences, Inc. (CALA), a clinical stage biotechnology company focused on discovering and developing novel small molecule drugs for the treatment of cancer and other life-threatening diseases, today announced that new data from its research and development portfolio will be featured in two poster presentations at the upcoming Society for Immunotherapy of Cancer (SITC) 34th Annual Meeting 2019 in National Harbor, Maryland, taking place November 6-10.
“The preclinical IL4I1 immuno-oncology program is an exciting new addition to our pipeline, and we are pleased that initial data from this program, as well as our ongoing CB-708 preclinical program, have been accepted for presentation at this high-profile meeting,” said Susan Molineaux, PhD, president and chief executive officer of Calithera. “IL4I1 represents a novel target for cancer immunotherapy and aligns with Calithera’s clinical focus on onco-metabolism. The presentation of early-stage data from both the IL4I1 and CB-708 programs demonstrate Calithera’s rigorous approach to scientific exploration and support the further development of these compounds, which we believe to have significant potential to improve cancer treatment.”
Details of the poster presentations are as follows:
|Title:||Anti-tumor activity of a small molecule inhibitor of the immuno-suppressive enzyme Interleukin 4 (IL-4)-Induced Gene 1 (IL4I1)|
|Date:||Friday, November 8, 2019 at 7:00 am-8:00 pm ET|
|Title:||CB-708, an orally bioavailable small molecule inhibitor of CD73 with immunostimulatory and anti-tumor activity|
|Date:||Saturday, November 9, 2019 at 7:00 am-8:30 pm ET|
IL4I1 is an enzyme that is primarily expressed by tumor cells and antigen presenting cells, and produces hydrogen peroxide, an inhibitor of T-cell function. IL4I1 has a potential role in immune evasion and decreases the ability of checkpoint therapy to mount an anti-tumor immune response. Calithera’s pipeline includes an investigational first-in-class, potent, orally available IL4I1 inhibitor.
CB-708 is a small molecule inhibitor of CD73, which is an enzyme in the tumor microenvironment that produces adenosine, a powerful inhibitor of immune function in tumors. CD73 is expressed across a wide range of tumor types and tumor infiltrating leukocytes. Expression of CD73 often correlates with poor prognosis in patients with cancer. Blockade of adenosine production by CD73 inhibition is expected to reverse immunosuppression in the tumor microenvironment and enhance the immune system’s ability to fight the cancer. CB-708 is orally bioavailable and shows distribution to all tissues, including the brain.
Calithera Biosciences is a clinical-stage biopharmaceutical company pioneering the discovery and development of targeted therapies that disrupt cellular metabolic pathways to preferentially block tumor cells and enhance immune-cell activity. Driven by a commitment to rigorous science and a passion for improving the lives of people impacted by cancer and other life-threatening diseases, Calithera is advancing a pipeline of first-in-clinic, oral therapeutics to meaningfully expand treatment options available to patients. Calithera is headquartered in South San Francisco, California. For more information about Calithera, please visit www.calithera.com.
Forward Looking Statements
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SOURCE: Calithera Biosciences, Incorporated