LAS VEGAS, Sept. 17, 2020 /PRNewswire/ -- The coming decade is expected to witness a rise in targeted therapies in the pipeline and a better drug delivery approach that shall give the cervical cancer market a boost. An increase in cervical cancer incidence is also a major reason behind the accelerated momentum of the cervical cancer market size growth. Further, increased healthcare spending, better diagnosis, and heightened R&D to facilitate a better understanding and increased awareness of the disease are some other driving factors.
Some of the key insights from cervical cancer market report:
The incidence of cervical cancer in 7MM (US, UK, Germany, Italy, Spain, France & Japan) in 2020 is expected to be 43,712.
In the 7MM, the USA is the major contributor to the cervical cancer market revenue in 2020, and the region is expected to hold its position in the upcoming years.
Key companies propelling the market size include Regeneron, AstraZeneca, Lovance, Zeria Pharmaceutical, Seattle Genetics/Genmab, Agenus Bio, Roche, Akeso Biopharma and Vaccibody/Roche, among others.
Launch of cervical cancer pipeline therapies, including Cemiplimab (Regeneron), Durvalumab (AstraZeneca), LN-145 (Iovance), Z-100 (Zeria Pharmaceutical), Tisotumab vedotin (Seattle Genetics/Genmab) in the next decade is expected to propel the market growth.
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Cervical cancer is a cause of infection from Human papillomavirus (HPV), which can be prevented. Due to its slow progression, the precancerous cells can be detected through proper screening with a Pap smear test and HPV test; and can be prevented through HPV vaccination (Cervarix and Gardasil 9). However, a lack of awareness and misconceptions hinder screening and its early diagnosis.
DelveInsight estimated that cervical cancer is most often diagnosed in women between the ages of 35 and 44, with the average age at diagnosis being 50. The late diagnosis in women is a consequence of a lack of vaccination and screening in women in the early stages of their lives.
For cancer, which is preventable in the first place, the mortality rate due to advanced cervical cancer is relatively high. However, the rate varies with the different stages of cancer, geographies, ethnicities, and age-groups.
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The cervical cancer epidemiology section in the report provides historical and forecasted analysis upto 2030 segmented by:
Incident cases of Cervical Cancer
Stage-specific Incidence of Cervical Cancer
Histopathologic Types of Cervical Cancer
Age-specific causes of Cervical Cancer
The present treatment market for cervical cancer is mainly bifurcated into therapeutics and preventive. The preventive cervical cancer treatment market comprises two candidates, namely Cervarix (Merck) and Gardasil (GlaxoSmithKline).
For advanced, metastatic cervical cancer, the available treatments in the market constitute traditional chemotherapies, targeted monoclonal antibodies, biosimilars, and immunotherapies. Targeted therapies such as Avastin have revolutionized the treatment landscape for cervical cancer, which are often given in combination with chemotherapy. Avastin has enjoyed market exclusivity and has been a top-earner of Roche. However, after its patent expiry in 2019 in the US, it faced rigorous competition from Amgen's Mvasi, Pfizer's Zirabev, and Samsung's Aybintio. The sales of the therapy have declined in the US due to the approvals of copycats, which are priced considerably lower than the original one. The sales of the drug will decline in the European market in January 2022 due to a similar fate.
The cervical cancer market also homes Merck's star, Keytruda, which got approval in 2018 for advanced cervical cancer for PD-L1 positive patients. Keytruda is the only approved immunotherapy in the cervical cancer market landscape; hence it enjoys the monopoly in the domain. However, sooner it will be vying for dominance as Regeneron and Sanofi's contender Libtayo is proceeding towards the finish line. Furthermore, to minimize the effect of inevitable patent expiry, Merck is testing a combination of Keytruda with Chemoradiotherapy for patients with high-risk locally advanced cervical cancer (NCT04221945). Enrolment is ongoing for Phase III, and the study is expected to be completed by the end of 2024.
Recently, at ASCO 2020, Genmab demonstrated the positive benefit-to-risk profile of its drug Tisotumab vedotin, a first-in-class antibody-drug conjugate directed against tissue factor (TF). Now the company plans to investigate the drug in combination with other cancer drugs, namely Bevacizumab, Pembrolizumab, and Carboplatin in a Phase Ib/II trial to find out the correct dosage in recurrent or metastatic cervical cancer (NCT03786081).
The Cervical cancer market has several treatment drugs in the late-stage as well as early phase of development in the pipeline. The expected launch of pipeline therapies in the foreseeable future shall significantly impact the Cervical cancer market. A better understanding of the HPV and its interaction with the host has given rich insights into the therapeutic domain.
Further, the launch of prophylactic as well as therapeutic vaccines, will transform the cervical cancer treatment landscape. Prophylactic cancer vaccines have been successful in dampening the disease burden; however, they cannot help the patients with established tumors, which Scientists believe can be tackled by the use of therapeutic vaccines. However, the neoantigens that are the basis of the therapeutic cancer vaccine are unique to patients thus, it requires the development of personalized therapies. Among all the candidates in the distant pipeline, only one to reach Phase III is VGX-3100, a candidate of Inovio Pharmaceuticals.
Also, research is underway to identify therapeutic targets and develop curative therapy to treat cervical cancer. Scientists are investigating the potential of biomarkers among cervical cancer patients that shall define the screening and diagnosis of cancer to a greater extent. A combination of multiple potential biomarkers, including serum proteins, microRNAs, ctDNA mutations, and others, can significantly increase the sensitivity of the screening and detection of cervical cancers.
Although cervical cancer market growth may face obstructions in the face of lack of awareness among common people, delayed diagnosis, high cost of treatment, and palliative treatment options for metastatic cancer. Nevertheless, the renewed interest in targeted therapies, personalized medicine, and rising R&D that has facilitated the identification of actionable biomarkers offer a promising and flourishing environment to the global cervical cancer market.
Scope of the Report
Geography Covered: 7MM - The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan.
Study Period: 3-year historical and 11-year forecasted analysis (2017-2030).
Markets Segmentation: By Geographies, By Therapies (Forecasted + Historical).
Companies Covered: Regeneron, AstraZeneca, Iovance, Zeria Pharmaceutical, Seattle Genetics/Genmab, Agenus Bio, Roche, Akeso Biopharma, and Vaccibody/Roche among others.
Analysis: Comparative and conjoint analysis of emerging therapies, Attribute Analysis,
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Table of Contents
Executive Summary of Cervical Cancer
SWOT Analysis of Cervical Cancer
Cervical Cancer Epidemiology Overview at a Glance
Cervical Cancer Market Overview at a Glance
Disease Background and Overview: Cervical Cancer
Epidemiology and Patient Population
Country Wise-Epidemiology of Cervical Cancer
Cervical Cancer Treatment and Management
Unmet Needs in the Cervical Cancer Market
Cervical Cancer Marketed Therapies
Cervical Cancer Emerging Therapies
Cervical Cancer: Other Promising Therapies
Cervical Cancer 7 Major Market Analysis
7MM Cervical Cancer Country-Wise Analysis
Cervical Cancer Market Drivers
Cervical Cancer Market Barriers
*The TOC is illustrative, request for a detailed TOC.
Cervical Intraepithelial Neoplasia (CIN) or cervical dysplasia is a precancerous condition characterized by an unusual growth of the cells on the surface lining of the cervix or endocervical canal.
The report proffers a detailed section of the indication overview, signs symptoms, with a major focus on CIN epidemiology in the 7MM, present treatment modalities, and emerging therapies in the pipeline. The report lays down an in-depth understanding of the market landscape, key collaborations, partnerships, R&D development, and driving forces as well as restrains in the market growth.
Human Papillomavirus virus (HPV) is a cause of a significant burden on global healthcare. HPV infections, if neglected, can results in several diseases, including anogenital warts and recurrent respiratory papillomatosis and several forms of cancers.
The report provides rich insights into the indication, its etiology, pathogenesis, manifestation with an exclusive focus on historical as well as forecasted epidemiology and market trends. The report brings a comprehensive analysis of the market landscape, recent happenings, breakthroughs, key partnerships, present and emerging treatments, market barriers, and drivers.
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing end to end comprehensive solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.
SOURCE DelveInsight Business Research, LLP