A Comprehensive Analysis of 18+ Key Companies Strengthening Chronic Spontaneous Urticaria Pipeline | Insights by DelveInsight

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For the treatment of Chronic Spontaneous Urticaria, there are several drugs being developed by different pharmaceutical industries with different routes of administration like oral, subcutaneous, intravenous which could be chosen according to the affordability and feasibility of an individual.

Los Angeles, June 08, 2021 (GLOBE NEWSWIRE) -- A Comprehensive Analysis of 18+ Key Companies Strengthening Chronic Spontaneous Urticaria Pipeline | Insights by DelveInsight

For the treatment of Chronic Spontaneous Urticaria, there are several drugs being developed by different pharmaceutical industries with different routes of administration like oral, subcutaneous, intravenous which could be chosen according to the affordability and feasibility of an individual.

DelveInsight’s ‘Chronic Spontaneous Urticaria Pipeline Insights’ report offers a holistic coverage of the current treatments and pipeline therapies and landscape in different stages of development from pre-clinical till late-stage, along with dormant, inactive and abandoned therapeutic agents.

Some of the key pointers from the Chronic Spontaneous Urticaria Pipeline report:

  • Chronic Spontaneous Urticaria Pipeline report offers a rich analysis of 18+ key players actively working in the space developing over 18+ key therapies.

  • Chronic Spontaneous Urticaria pipeline comprises therapies in different stages of trials such as UB-221, GBR 310, Ligelizumab, UCB8600, Antolimab, Dupilumab, GI-301, CDX-0159, LY3454738, among others.

  • Key pharma companies involved in accelerating the drug development for Chronic Spontaneous Urticaria include Allakos, AstraZeneca, Biosana, Celldex Therapeutics, Celltrion, Eli Lilly and Company, Genentech, GI Innovation/Yuhan, GlaxoSmithKline, Glenmark Pharmaceuticals, Gossamer Bio, Kiniksa Pharmaceuticals, Mycenax Biotech, Novartis, Regeneron, Synermore Biologics, UCB Biopharma, United BioPharma, among others.

  • DelveInsight estimates that Ligelizumab, a next-generation high-affinity humanized monoclonal anti-IgE antibody is expected to emerge as a potential therapeutic agent owing to the treatment.

  • Celltrion has initiated the clinical trials of its CT-P39, a biosimilar of omalizumab (Xolair), to Phase 3 trials in November 2020.

  • United BioPharma obtained Taiwan FDA approval for conducting a phase I clinical trial of its UB21 product, a third-generation monoclonal anti-IgE antibody and initiated a phase I clinical trial in May 2020.

  • The U.S. Food and Drug Administration (FDA) has granted ligelizumab (QGE031) Breakthrough Therapy designation for the treatment of Chronic Spontaneous Urticaria (CSU) in patients who have an inadequate response to H1-antihistamine treatment.

  • Tezepelumab is a human monoclonal antibody that inhibits the action of the thymic stromal lymphopoietin (TSLP). It is being developed and investigated for the treatment of Chronic Spontaneous Urticaria (CSU) by Amgen in collaboration with AstraZeneca.

  • Celldex Therapeutics has initiated Phase 1b studies of CDX-0159 in chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CINDU), both mast cell-related diseases, in the fall of 2020.

  • Lirentelimab (AK002) being developed by Allakos, targets Siglec-8, an inhibitory receptor found on the surface of mast cells and eosinophils. Allakos has completed an open-label Phase 2a clinical trial evaluating lirentelimab in patients with multiple forms of Chronic Urticaria.

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Chronic Spontaneous Urticaria: Overview

Chronic Urticaria (CU) is a condition of the skin caused by a plenitude of factors such as environmental irritants, your immune system, genetics, or in response to a bacterial, fungal, or viral infection. Based on the cause, it can be of two types Chronic Idiopathic Urticaria (also called chronic spontaneous urticaria) and Chronic Inducible Urticaria (also called physical urticaria).

Chronic Spontaneous Urticaria was previously referred to as Chronic Idiopathic Urticaria, however, the term is no longer used as many cases have an autoimmune basis.

For more information on emerging drugs, visit Chronic Spontaneous Urticaria Pipeline Analysis

Chronic Spontaneous Urticaria Drug Pipeline Assessment

Drug

Company

Phase

MoA

RoA

UB-221

United BioPharma

I

IgE receptor antagonists; Immunomodulators

Intravenous

GBR 310

Glenmark Pharmaceuticals

II

IgE receptor antagonists; Immunosuppressants

Subcutaneous

Ligelizumab

Novartis

III

IgE receptor antagonists

Subcutaneous

UCB8600

UCB Biopharma

I

NA

Oral

Antolimab

Allakos

II

Antibody-dependent cell cytotoxicity; Immunomodulators; Mast cell inhibitors

Intravenous

Dupilumab

Regeneron/Sanofi

III

Interleukin 13 inhibitors; Interleukin 4 inhibitors

Subcutaneous

GI-301

GI Innovation/Yuhan

Preclinical

Free IgE suppression

Parenteral

CDX-0159

Celldex Therapeutics

I

KIT Inhibitor

Subcutaneous

LY3454738

Eli Lilly and Company

II

CD200R1 protein stimulants

Intravenous

Fenebrutinib

Genentech

II

Bruton’s tyrosine kinase inhibitor

Oral

GS-4059

Gilead sciences

II

Agammaglobulinaemia tyrosine kinase inhibitors

Oral

Tezepelumab

Amgen

II

Thymic stromal lymphopoietin inhibitors

Subcutaneous

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Chronic Spontaneous Urticaria Therapeutics Assessment

The Chronic Spontaneous Urticaria Pipeline report proffers comprehensive coverage of the active pipeline candidates segmented by Stage, Product Type, Route of Administration, Molecule Type, Target, and Mechanism of Action.

By Product Type

  • Mono

  • Combination

By Stage

  • Discovery

  • Pre-clinical

  • IND

  • Phase I

  • Phase II

  • Phase III

  • Pre-registration

By Molecule Type

  • Monoclonal Antibody

  • Peptides

  • Polymer

  • Small molecule

  • Gene therapy

  • Product Type

By Route of Administration

  • Oral

  • Parenteral

  • Intravenous

  • Subcutaneous

  • Topical

  • Molecule Type

By Mechanism of Action

  • IgE receptor antagonists

  • Mast cell inhibitors

  • Interleukin 13 inhibitors

  • KIT Inhibitor

  • Free IgE suppression

  • Thymic stromal lymphopoietin inhibitors

  • Agammaglobulinaemia tyrosine kinase inhibitors

  • CD200R1 protein stimulants

  • Antibody-dependent cell cytotoxicity; Immunomodulators

By Targets

  • Proteins

  • Immunoglobulin

  • Interleukins

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Scope of the Chronic Spontaneous Urticaria Pipeline Report

Coverage: Global
Key Players: Allakos, AstraZeneca, Biosana, Celldex Therapeutics, Celltrion, Eli Lilly and Company, Genentech, GI Innovation/Yuhan, GlaxoSmithKline, Glenmark Pharmaceuticals, Gossamer Bio, Kiniksa Pharmaceuticals, Mycenax Biotech, Novartis, Regeneron, Synermore Biologics, UCB Biopharma, United BioPharma, Amgen, and others.
Key Chronic Spontaneous Urticaria Pipeline Therapies: UB-221, GBR 310, Ligelizumab, UCB8600, Antolimab, Dupilumab, GI-301, CDX-0159, LY3454738, Fenebrutinib, GS-4059, Nucala, SYN008, BP001, Tezepelumab and others.

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Table of Contents

1

Report Introduction

2

Chronic Spontaneous Urticaria Disease Overview

3

Chronic Spontaneous Urticaria Pipeline Therapeutics

4

Therapeutic Assessment

5

Chronic Spontaneous Urticaria – DelveInsight’s Analytical Perspective

6

In-depth Commercial Assessment

7

Chronic Spontaneous Urticaria Collaboration Deals

8

Chronic Spontaneous Urticaria Therapeutic Products in Clinical Stage

9

Chronic Spontaneous Urticaria Therapeutic Products in Non-clinical Stage

10

Chronic Spontaneous Urticaria Therapeutics Pipeline Analysis

11

Inactive Chronic Spontaneous Urticaria Pipeline Products

12

Chronic Spontaneous Urticaria Key Companies

13

Chronic Spontaneous Urticaria Key Products

14

Chronic Spontaneous Urticaria- Unmet Needs

15

Appendix

16

Report Methodology

17

Consulting Services

18

Disclaimer

19

About DelveInsight

Learn more about the report offerings @ Chronic Spontaneous Urticaria Emerging Therapies, Treatments and Ongoing Clinical Trials

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