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Esperion Therapeutics Reports Sooner Than Expected Positive Data From Nexletol Trial

  • Esperion Therapeutics Inc's (NASDAQ: ESPR) CLEAR Outcomes trial met its primary endpoint, demonstrating statistically significant risk reduction in MACE-4 in patients treated with 180 mg/day NEXLETOL (bempedoic acid) compared to placebo.

  • The data demonstrate statistically significant and clinically meaningful results.

  • The study included over 14,000 patients at over 1,200 sites in 32 countries.

  • Bempedoic acid becomes the first ATP citrate lyase inhibitor and oral non-statin to meet the major adverse cardiovascular events (MACE-4) primary endpoint.

  • NEXLETOL is indicated as an adjunct to diet and maximally tolerated statin therapy for heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.

  • The company reported CLEAR Outcomes trial data sooner than expected in January 2023.

  • In Q3, NEXLETOL generated sales of $14 million, up 28% Y/Y.

  • The company looks forward to sharing this data with the medical community and submitting it to appropriate regulatory authorities as quickly as possible in 2023.

  • Price Action: ESPR shares are up 2.55% at $7.25 on the last check Wednesday.

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