"My heart breaks for all the women who have suffered tremendous pain because of these unforgivable actions," Chapman said in a statement to People magazine. "I have chosen to leave my husband. Caring for my young children is my first priority and I ask the media for privacy at this time."
Chapman, a prominent designer and the cofounder of the Marchesa brand, married Weinstein in 2007. The couple has two children: India Pearl, 7, and Dashiell Max Robert, 4.
Many actresses — including Renée Zellweger and Cate Blanchett, who have both starred in Weinstein-produced films — have worn Marchesa dresses on the red carpet at Hollywood events, and rumors have floated for years that Weinstein pushed actresses to wear the fashion brand.
Weinstein was fired on Sunday from his eponymous company, The Weinstein Company, after The New York Times detailed numerous sexual-harassment allegations against him in a bombshell report. Weinstein's attorney, Charles Harder, says he is preparing to sue The Times.
Manhattan's district attorney, Cyrus Vance Jr., declined to file charges against Weinstein in 2015 after the Italian model Ambra Battilana Gutierrez said Weinstein assaulted her, The New Yorker reported on Tuesday. During the investigation, police obtained an audio recording of Weinstein in which he acknowledged that he had groped Gutierrez, the magazine said.
Weinstein is flying to a rehab center in Europe to seek treatment for sex addiction, TMZ reported on Tuesday evening. An unnamed source told TMZ that Weinstein was "pretty calm" but that he had "moments where there are bursts."
Before the fallout over the allegations exploded this week, Weinstein reportedly had begged Hollywood power players for help to keep his job at The Weinstein Company.
Mark Abadi contributed reporting.
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