Will a home office deduction trigger an audit? The answer is generally "no." Changes in the rules in the late 1990s made it easier for people who work out of their homes to qualify for these write-offs. So if you qualify, by all means, take it. Generally speaking, to qualify for the home office deduction you must be able to satisfy the three main rules: Exclusive use, regular use, and principal place of business. There are some exceptions to these rules, such as for daycare and storage facilities. Keep reading to find out if you qualify for the home office tax deduction.