Iovance Shares Tumble After Cell Therapy Data From Lung Cancer Trial

• Iovance Biotherapeutics Inc (NASDAQ: IOVA) has announced additional data for LN-145 in patients with metastatic non-small cell lung cancer (mNSCLC) enrolled in Cohort 3B of the basket study IOV-COM-202.

• The results demonstrate the feasibility of LN-145, a tumor-infiltrating lymphocyte TIL cell therapy in heavily pre-treated patients.

• Following one-time treatment with LN-145 monotherapy, the overall response rate (ORR) is 21.4% in the full analysis set (n=28) and 25% in the efficacy-evaluable set (n=24), including one complete response (CR) and five partial responses (PR).

• One complete response and one partial response are ongoing at 20.7 months and 3.0 months, respectively, at a median study follow-up of 9.8 months.

• Iovance is enrolling patients in the IOV-LUN-202 study to investigate LN-145 in second-line mNSCLC where patients have progressed on prior ICI and chemotherapy.

• Price Action: IOVA shares are down 15.4% at $19.88 during the market session on the last check Friday.

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