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Isis Pharmaceuticals initiates Phase 1 study of ISIS-ANGPTL3 Rx

Isis Pharmaceuticals nannounced that it has initiated a Phase 1 clinical study for ISIS-ANGPTL3 Rx, an antisense drug targeting angiopoietin-like 3 protein, an independent risk factor for cardiovascular disease. ISIS-ANGPTL3 Rx is designed to act as a broad dyslipidemia agent. By reducing ANGPTL3, ISIS-ANGPTL3 Rx has the potential to reduce LDL-cholesterol and triglycerides, and to increase insulin sensitivity. Isis plans to evaluate ISIS-ANGPTL3 Rx in patients who have severe metabolic or cardiovascular disease and who would benefit from a drug that simultaneously addresses a variety of adverse lipid and metabolic parameters contributing to their disease.