The actress, 50, enjoyed a record-breaking start to life on Instagram when her account became the fastest to reach one million followers.
Aniston managed the feat in just five hours and 16 minutes after posting a selfie of her and her Friends co-stars back in October.
The Morning Show star is now celebrating another milestone, having reached 20 million followers.
Alongside a video of herself wiping tears from her eyes, she wrote: “20 million followers?! That’s a lot of thank you notes! THANK YOU, GUYS.”
Last month, she explained why she finally decided to join social media.
Speaking on The Ellen DeGeneres Show, Aniston said: “It was just one of those things. Eventually – it’s not going anywhere, right? So why not join the party?
“And it’s not that scary. [You can] share information, connect with your fans, right wrongs that are said about you, have fun, make fun of yourself, make fun of people. Help animals get rescued.”