JNJ's Imbruvica, AbbVie's Venclexta Combo Achieves Progression-Free Survival Of 78.4% Versus Gazyva-Chemo Cocktail In Leukemia Patients

Vandana Singh
1 min read
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In this article:

  • A combination of Johnson & Johnson’s (NYSE: JNJ) Imbruvica and AbbVie Inc (NYSE: ABBV) - Roche Holding AG’s (OTC: RHHBY) Venclexta/Venclyxto (venetoclax) slashed the risk of cancer progression or death by 78.4% compared with a cocktail of Roche’s Gazyva and the chemotherapy chlorambucil in previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) patients.

  • The phase 3 GLOW trial data were shared at the European Hematology Association (EHA) annual meeting.

  • In the preliminary analysis of the GLOW trial, at three months after treatment ended, 51.9% of the Imbruvica-Venclexta combo patients had undetectable measurable residual disease (uMRD), stringent marker reflecting no signs of cancer in bone marrow, versus 17.1% for the control group.

  • The rates for peripheral blood were 54.7% and 39% for the two groups, respectively.

  • From the three-month point onward, 84.5% of uMRD patients maintained that deep remission in the blood to the 12-month assessment.

  • The complete response rate was also significantly higher with Imbruvica-Venclexta combo vs. Gazyva and chlorambucil (38.7% vs. 11.4%).

  • The overall response rate was not significantly different between both arms. Time to subsequent therapy was longer for the Imbruvica-Venclexta combo.

  • See the abstract here.

  • Price Action: JNJ shares closed at $164.96, ABBV closed at $115.42, and RHHBY closed at $47.56 on Friday.

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