CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)--
– KVD900 Demonstrates Rapid and Nearly Complete Suppression of Plasma Kallikrein Activity in a Phase 1 Study –
KalVista Pharmaceuticals, Inc. (KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors announced data was presented at the European Academy of Allergy and Clinical Immunology (EAACI) Congress in Lisbon, Portugal.
“We continue recruiting for our Phase 2 clinical trial of KVD900,” said Andrew Crockett, Chief Executive Officer of KalVista. “In the meantime, we are pleased to show more of KVD900’s strong Phase 1 data that makes it such a great candidate for potential oral on-demand treatment of hereditary angioedema.”
The poster presented data, including:
- Administration of KVD900 led to complete inhibition of plasma kallikrein activity (>99%) in stimulated whole plasma
- Inhibition of plasma kallikrein resulted in strong protection of high molecular weight kininogen for up to 12 hours
- Rapid absorption to effective concentrations was unaffected by food
About KalVista Pharmaceuticals, Inc.
KalVista Pharmaceuticals, Inc. is a pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors for diseases with significant unmet need. The initial focus is on inhibitors of plasma kallikrein, which is an important component of the body’s inflammatory response and which, in excess, can lead to increased vascular permeability, edema and inflammation. KalVista has developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME). The Company has created a structurally diverse portfolio of oral plasma kallikrein inhibitors and is advancing multiple drug candidates for HAE as well as DME. The Company has selected KVD900 as its program to be advanced as an on-demand therapy for HAE attacks and commenced a Phase 2 proof-of-concept study in HAE patients in late 2018. In DME, KalVista’s most advanced program, an intravitreally administered plasma kallikrein inhibitor known as KVD001, began a Phase 2 clinical trial in 2017 that is anticipated to complete in the second half of 2019.
For more information, please visit www.kalvista.com.
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