City dominated at Old Trafford two weeks ago and take a 3-1 lead into the game at the Etihad.
Pep Guardiola insists he is wary of United's threat but it will take an astonishing night for Ole Gunnar Solskjaer's side to progress to the final.
“We've done amazing things before at this club," said Solskjaer, "and with these players and the PSG game is for me a very good example how you can make a two-goal deficit work in your favour because we need the first goal."
Here's everything you need to know:
Manchester City: Bravo, Walker, Rodrigo, Otamendi, Cancelo, Gundogan, Mahrez, De Bruyne (c), Bernardo, Sterling, Aguero.
Subs: Ederson, Stones, G Jesus, Zinchenko, D Silva, Foden, Garcia.
Manchester United: De Gea, Wan-Bissaka, Lindelof, Maguire (c), Shaw, Williams, Fred, Matic, Lingard, Greenwood, Martial.
Subs: Romero, Bailly, Dalot, Jones, Andreas, James, Mata.
Manchester City 1/3
Manchester United 17/2
City are just too good for this United team. City 1-0 United.