Ole Gunnar Solskjaer’s team beat Watford 3-0 at the weekend to make it six matches without defeat across all competitions.
Philippe Clement also guided his team to victory, 1-0 against Sporting Charleroi, to stay nine points clear at the top of the Belgian Jupiler Pro League.
At Old Trafford for this second leg, both teams will be aiming to progress to the last 16 and boost confidence as they push for their respective domestic objectives.
Here’s everything you need to know about the match:
When is it and what time is kick-off?
The match starts at 8pm on Thursday 27
What TV channel is it on?
As with all UEFA competitions this season, BT Sport have the rights. The game will be broadcast on BT Sport 2 and BT Sport Ultimate.
Man Utd: Romero, Wan-Bissaka, Bailly, Maguire, Shaw, McTominay, Fred, Fernandes, Mata, James, Ighalo
Brugge: Mignolet, Mata, Mechele, Deli, Ricca, Kossounou, Vanaken, Rits, Tau, De Cuyper, Okereke
United should be confident after recent domestic wins over Chelsea and Watford and, even if Solskjaer changes the team around, they will have too much off the bench for Brugge to cope with.
Manchester United 2-1 Club Brugge (3-2 on aggregate)
Man United 4/9
Club Brugge 7/1