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Merck and United jump while Signet and SuperValu fall

NEW YORK (AP) -- Stocks that moved substantially or traded heavily on Wednesday:

Merck & Co., up $1.71 to $61.63

The company said that regulators will perform a fast review of an application that could boost sales of its cancer drug Keytruda.

United Continental Holdings Inc., up $1.38 to $75.04

The airline reported strong performance in December.

BorgWarner Inc., down 65 cents to $40.12

The auto parts supplier projected a weak annual profit and a surprise decline in sales.

Intuitive Surgical Inc., up $15.96 to $678.16

The robotic surgical system maker forecast solid revenue in the fourth quarter thanks to strong sales of instruments and accessories.

Stryker Corp., up $1.76 to $123.66

The medical device maker forecast better fourth-quarter sales than analysts expected.

Signet Jewelers Ltd., down $2.76 to $84.70

The company cut its profit estimates after sales fell over the holidays, partly because of problems for its e-commerce business.

SuperValu Inc., down 36 cents to $4.43

The grocery store operator announced a weak third-quarter profit, partly because of falling food prices.

Public Storage, down $5.54 to $219.76

Real estate investment trusts traded lower than the broader market on Wednesday.