The Gunners have a 2-0 to defend courtesy of an Aaron Ramsey strike and a Kalidou Koulibaly own goal.
However, Napoli are a formidable outfit at the San Paolo, with Liverpool one of many teams to have fallen to defeat in Naples this season.
The winner of this tie will face the winner of the Villarreal and Valencia tie – Valencia have a 3-1 lead from the first leg.
Here’s all the information you need to know:
When is the game and where do I watch it?
Napoli vs Arsenal kicks-off at 8:00pm (BST) on Thursday 18 April.
The match is live on BT Sport 2, with coverage starting from 7:15pm.
Subscribers can stream the match via the BT Sport app.
And we will of course be providing live text coverage throughout this evening’s game on The Independent.
The big injury doubt for Arsenal is the fitness of dynamic midfielder Lucas Torreira. The Uruguayan was substituted at half time on Monday with a groin injury, but has travelled with the squad.
One man who will be fresh is Sokratis Papastathopoulos, who is likely to come into the starting XI after being banned for Monday’s game at Watford.
For Napoli, Spanish defender Raul Albiol and midfielder Amadou Diawara are likely to miss out.
Napoli: Meret, Hysaj, Koulibaly, Maksimovic, Rui, Allan, Zielinski, Callejon, Ruiz, Milik, Insigne
Arsenal: Cech, Sokratis, Koscielny, Monreal, Maitland-Niles, Kolasinac, Torreira, Xhaka, Ramsey, Ozil. Lacazette
This is a tricky one to call. Arsenal are on a decent run of form, both in Europe and domestically. But there are a number of factors which weigh against them this evening.
Napoli’s home form is in stark contrast to their away form in European competitions. This season, they have beaten Liverpool, Red Star Belgrade, FC Zurich, Red Bull Salzburg and have held PSG at the San Paolo.
Furthermore, they have won 10 of their last 13 home games in all competitions. Conversely, Arsenal’s performances in the Europa League knockout stages have been poor: two defeats, to BATE Borisov and Rennes. In addition, Arsenal have hardly had adequate preparation for this game. The ridiculous, television-based decision resulted in Arsenal playing against Watford on Monday night, compared to Napoli who played on Sunday.
And yet Arsenal can take enormous heart from their convincing display in the first leg, when arguably they should have put the tie out of sight. That could yet be their downfall, but one goal in Italy means Napoli would have to score four. With that fact in mind, it’ll be fascinating to see how Emery sets up his side this evening – stick or twist?
It will be tight, and could feasibly go to extra-time if Arsenal don’t score, but a goal should see them home. 2-1 Napoli, Arsenal through to the semis (3-2 agg.)