Needham Previews Neurocrine's Upcoming Mid-Stage Data from Essential Tremor Study

Vandana Singh

Mon, Jul 11, 2022, 2:20 PM1 min read

In this article:

Needham previews the upcoming Phase 2 data readout for Neurocrine Biosciences Inc's (NASDAQ: NBIX) NBI-827104, a t-type calcium channel blocker in essential tremor (ET), by mid-2022.
The analyst notes that though NBI-827104 lags behind its competitors, the market opportunity will be attractive given the total addressable market estimated at ~$13 billion, with no recently approved drugs in ET.
The following data readout for Jazz Pharmaceuticals PLC (NASDAQ: JAZZ) and Praxis Precision Medicines Inc's (NASDAQ: PRAX) second Phase 2 trials are expected in 1H of 2024 and 2H of 2022, respectively.
Commenting on efficacy, given a similar mechanism of action to Jazz's JZP385 and Praxis' PRAX-944, Needham looks for a change in TETRAS-ADL of 5-6 points and TETRAS-ADL of 4-5 points.
TETRAS is designed for the rapid and valid assessment of ET severity.
On safety, JZP385 and PRAX-944 both had ~20% discontinuations.
The analyst says that if NBI-827104's safety profile can replicate its Phase 1 (~10% discontinuation).
Needham expects a single-digit upside to shares on a successful study.
Price Action: NBIX shares are up 1.77% at $97.26 during the market session on the last check Monday.

Latest Ratings for NBIX

Date	Firm	Action	From	To
Mar 2022	Piper Sandler	Downgrades	Overweight	Neutral
Feb 2022	Goldman Sachs	Upgrades	Neutral	Buy
Feb 2022	Morgan Stanley	Maintains		Equal-Weight

View More Analyst Ratings for NBIX

View the Latest Analyst Ratings

See more from Benzinga

Don't miss real-time alerts on your stocks - join Benzinga Pro for free! Try the tool that will help you invest smarter, faster, and better.

Mark Zuckerberg got $24.4 million in ‘other compensation’ in 2023—but Meta also treated staff well, with the median employee making $379,000
On paper, Mark Zuckerberg is Meta’s lowest-paid employee, with a $1 dollar salary and no bonus.
Fortune•11h ago
Meta stock plummets 10% after second quarter outlook disappoints
Meta reported its Q1 earnings after the bell, beating analysts' expectations on the top and bottom, but a disappointing Q2 forecast sent shares falling.
Yahoo Finance•2h ago
$433 Billion Gone! One Stock Loses More Value Than Tesla
Tesla's loss of $328.3 billion this year in stock value certainly hurts. But it's only the second-largest market value loss in the S&P 500.
Investor's Business Daily•10h ago
Suze Orman Decided To Drop Homeowners Insurance After An Outrageous Quote: '$28,000 For A 2,100-Square-Foot Condo. Are You Kidding Me?'
Finance expert Suze Orman has voiced concerns about the impact of climate change on property insurance costs, asserting it could threaten the American dream of homeownership. Orman, 72, faced a $28,000 annual insurance quote for her Florida oceanside condo, leading her to forego coverage entirely. She highlights a troubling trend where soaring insurance costs driven by frequent and severe weather events may deter Americans from buying homes. Don't Miss: For many first-time buyers, a house is abo
Benzinga•1d ago
Meta shares sink as AI doubts rise
Shares in Meta plunged on Wednesday after the US tech giant revealed plans to increase spending on artificial intelligence (AI) technology.
The Telegraph•1h ago
Ford tops Q1 earnings expectations, sees full-year profit 'tracking to high-end' of guidance
Ford reported first quarter results after the bell that beat expectations on Wednesday, with its changing product game plan front and center along with its focus on gas and hybrid offerings.
Yahoo Finance•8m ago
Chipotle blows by earnings estimates as resilient foot traffic, margin expansion boost Q1 results
Chipotle posted another strong quarter against a difficult macro backdrop.
Yahoo Finance•27m ago
JPMorgan’s ‘Bloody Friday’: Why Several Top Financial Advisors Jumped Ship the Same Day
Six teams managing nearly $15 billion in total assets quit JPMorgan Chase’s brokerage unit to join competitors last Friday. Here’s what may have triggered their departures.
Barrons.com•1d ago
Florida’s Home Insurance Industry May Be Worse Than Anyone Realizes
(Bloomberg) -- Seven property insurers in Florida went bankrupt in 2021 and 2022. The bankruptcies left thousands of homeowners scrambling to get new coverage, which often came with a big increase in cost. Worse, many had outstanding claims for hurricane damage that had not been addressed.Most Read from BloombergBiden’s Gains Against Trump Vanish on Deep Economic Pessimism, Poll ShowsTaylor Swift Is Proof That How We Critique Music Is BrokenTech Giants Hit in Late Hours After Meta’s Outlook: Mar
Bloomberg•2h ago
The IRS says it’s going after wealthy tax cheats. Here’s what new audit stats show.
After Congress approved billions of extra funding for tax compliance, the Internal Revenue Service pledged it would get tougher on rich taxpayers and corporations while avoiding extra scrutiny of middle-class households.
MarketWatch•1d ago

News

Life

Entertainment

Finance

Sports

New on Yahoo

Yahoo Finance

Needham Previews Neurocrine's Upcoming Mid-Stage Data from Essential Tremor Study

Latest Ratings for NBIX

Recommended Stories

Mark Zuckerberg got $24.4 million in ‘other compensation’ in 2023—but Meta also treated staff well, with the median employee making $379,000

Meta stock plummets 10% after second quarter outlook disappoints

$433 Billion Gone! One Stock Loses More Value Than Tesla

Suze Orman Decided To Drop Homeowners Insurance After An Outrageous Quote: '$28,000 For A 2,100-Square-Foot Condo. Are You Kidding Me?'

Meta shares sink as AI doubts rise

Ford tops Q1 earnings expectations, sees full-year profit 'tracking to high-end' of guidance

Chipotle blows by earnings estimates as resilient foot traffic, margin expansion boost Q1 results

JPMorgan’s ‘Bloody Friday’: Why Several Top Financial Advisors Jumped Ship the Same Day

Florida’s Home Insurance Industry May Be Worse Than Anyone Realizes

The IRS says it’s going after wealthy tax cheats. Here’s what new audit stats show.