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Novo Nordisk Completes Two Studies on Obesity Candidate

Zacks Equity Research
·2 mins read

Novo Nordisk A/S NVO announced headline results from two studies — a once-weekly subcutaneous amylin analogue or AM833 (as monotherapy) and a combination study of AM833 and once-weekly subcutaneous semaglutide 2.4 mg.

AM833 is an acylated long-acting analogue of the human amylin hormone that induces weight loss by reducing energy intake.

In the phase II monotherapy study,safety, tolerability and efficacy of AM833 wereinvestigated for weight management in 706 people with obesity or overweight with at least one weight-related comorbidity. The study reached its primary endpoint by demonstrating a weight loss of 10.8% at week 26 with AM833 at the 4.5 mg dose compared to a weight loss of 3.0 % with placebo.

The 20-week multiple ascending dose phase I study evaluated the weight loss potential of AM833 administrated in combination with semaglutide 2.4 mg in 80 people with obesity or overweight. Once-weekly subcutaneous semaglutide 2.4 mg is being investigated by Novo Nordisk as a treatment for adults with obesity.

After 20 weeks of treatment, participants receiving the highest dose lost 17.1% of body weight, on average, from a mean baseline body weight of 95.1 kg. The primary endpoint was the number of treatment-emergent adverse events and AM833 was well-tolerated, with the most common adverse events being gastrointestinal disorders, including nausea and vomiting, the majority being non-serious and mild or moderate in severity.

Shares of the company have gained 16.7% year to date against the industry’s decline of 1.8%.

Novo Nordisk has a strong presence in the diabetes care market with one of the broadest diabetes portfolios in the industry. However, the diabetes market is extremely crowded with players like Sanofi SNY, AstraZeneca AZN and Merck MRK.


Novo Nordisk AS Price


Novo Nordisk AS Price
Novo Nordisk AS Price

Novo Nordisk AS price | Novo Nordisk AS Quote

Zacks Rank

Novo Nordisk currently carries a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

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Novo Nordisk AS (NVO) : Free Stock Analysis Report
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