Mauricio Pochettino has rested Serge Aurier and Danny Rose and the pair have not made the trip to Athens.
In Mathieu Valbuena and Youssef Al-Arabi, the hosts have experience and quality at the top end of the pitch, and they have started the season well defensively – they are yet to concede after three league games.
With Bayern Munich and Red Star Belgrade the other two teams in Group B, Tottenham will be looking to get off to a strong start at the Karaiskaki Stadium.
Here’s everything you need to know about the game:
How can I watch?
BT Sport will be broadcasting the game on BT Sport 2, with coverage beginning at 17.15pm.
Can I stream the game online?
With a BT Sport subscription you can stream the match from your phone or tablet with the BT Sport app.
When is it?
The match begins at 17.55pm.
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Serge Aurier and Danny Rose have been rested and have not travelled to Greece with the Spurs squad, while Ryan Sessegnon, not long back from injury, has also been left in London.
Juan Foyth and Giovani Lo Celso are longer term absentees.
Olympiacos: Sa; Elabdellaoui, Cisse, Meriah, Koutris; Camara, Guilherme; Randelovic, Valbuena, Podence; El-Arabi
Tottenham: Lloris; Walker-Peters, Alderweireld, Vertonghen, Davies; Winks, Dier, Ndombele; Lucas, Kane, Dele
Tottenham should ultimately have too much quality for Olympiacos, but it could be a nervy affair in Athens.
Our prediction is Olympiacos 1-2 Tottenham.
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