Mauricio Pochettino’s side, beaten in the final last year, are in Group B, with Bayern Munich and Red Star Belgrade the two other sides with which Spurs have to contend.
After scraping through the group stages last year, Pochettino would prefer a more peaceful passage through to the knockout rounds, and an away victory at the Karaiskakis Stadium would set them on their way nicely.
But Olympiacos will pose a threat, adding creativity and potency this summer with Mathieu Valbuena and Youssef El-Arabi newly recruited to Athens.
Here’s everything you need to know about the game:
Tottenham should ultimately have too much quality for Olympiacos, but it could be a nervy affair in Athens.
Our prediction is Olympiacos 1-2 Tottenham.
When is it?
The match begins at 17.55pm.
- Read more
How can I watch?
BT Sport will be broadcasting the game on BT Sport 2, with coverage beginning at 17.15pm.
Can I stream the game online?
With a BT Sport subscription you can stream the match from your phone or tablet with the BT Sport app.
Serge Aurier and Danny Rose have been rested and have not travelled to Greece with the Spurs squad, while Ryan Sessegnon, not long back from injury, has also been left in London.
Juan Foyth and Giovani Lo Celso are longer term absentees.
Olympiacos: Sa; Elabdellaoui, Cisse, Meriah, Koutris; Camara, Guilherme; Randelovic, Valbuena, Podence; El-Arabi
Tottenham: Lloris; Walker-Peters, Alderweireld, Vertonghen, Davies; Winks, Dier, Ndombele; Lucas, Kane, Dele
Please allow a moment for the live blog to load