Pipeline Progress at OncoGenex

Zacks Equity Research

Thu, Feb 13, 2014, 3:45 PM

Pipeline updates are highly awaited events in the pharma/biotech sector as they play an important role in deciding whether or not to invest in a particular company. These companies spend a significant amount in advancing their pipelines. One such biopharma company is OncoGenex Pharmaceuticals, Inc. (OGXI) whose pipeline includes custirsen, apatorsen (OGX-427) and OGX-225.

Custirsen is the most advanced candidate in the pipeline. Recently, OncoGenex announced that the number of pre-determined events required for final analysis of custirsen has been reached in the phase III SYNERGY study.

The primary endpoint of the study will evaluate the overall survival benefit of the candidate, in combination with Sanofi’s (SNY) Taxotere as first-line chemotherapy, in metastatic castrate-resistant prostate cancer (:CRPC) patients.

OncoGenex expects final survival data from the study by mid 2014.

OncoGenex and partner Teva Pharmaceutical Industries, Ltd. (TEVA) are blinded to all data from the SYNERGY trial. We note that in Dec 2009, OncoGenex entered into a collaboration agreement with Teva for the development and global commercialization of custirsen.

Custirsen received Fast Track designation from the FDA for the treatment of progressive metastatic prostate cancer in combination with Taxotere.

Custirsen is in two other phase III studies, namely, ENSPIRIT and AFFINITY. ENSPIRIT is conducted in patients with advanced or metastatic non-small cell lung cancer (:NSCLC). The study is evaluating the potential survival benefit of custirsen plus Taxotere as second-line chemotherapy. The AFFINITY study is evaluating the overall survival benefit of custirsen plus Sanofi’s Jevtana (cabazitaxel) as second-line chemotherapy in patients with metastatic CRPC. OncoGenex expects to complete enrollment in this study by the end of 2014.

OncoGenex carries a Zacks Rank #3 (Hold). Investors looking for better-ranked stocks in the biopharma sector may consider Endocyte Inc (ECYT), which carries a Zacks Rank #1 (Strong Buy).

Read the Full Research Report on SNY
Read the Full Research Report on TEVA
Read the Full Research Report on ECYT
Read the Full Research Report on OGXI

Zacks Investment Research

Suze Orman Decided To Drop Homeowners Insurance After An Outrageous Quote: '$28,000 For A 2,100-Square-Foot Condo. Are You Kidding Me?'
Finance expert Suze Orman has voiced concerns about the impact of climate change on property insurance costs, asserting it could threaten the American dream of homeownership. Orman, 72, faced a $28,000 annual insurance quote for her Florida oceanside condo, leading her to forego coverage entirely. She highlights a troubling trend where soaring insurance costs driven by frequent and severe weather events may deter Americans from buying homes. Don't Miss: For many first-time buyers, a house is abo
Benzinga•2h ago
The IRS says it’s going after wealthy tax cheats. Here’s what new audit stats show.
After Congress approved billions of extra funding for tax compliance, the Internal Revenue Service pledged it would get tougher on rich taxpayers and corporations while avoiding extra scrutiny of middle-class households.
MarketWatch•5h ago
California McDonald's Franchise Owner Says, 'The Focus Is On Survival' With 'Unprecedented' $20 Per Hour Minimum Wage Forcing Higher Prices
In response to California's new $20 minimum wage law, fast food franchises are being forced to rethink their business strategies to stay afloat. Scott Rodrick, who owns 18 McDonald's franchises in the state, is considering measures to manage the increased labor costs without resorting to layoffs, which he sees as a last resort. Don't Miss: 82% of Americans aren’t using this government secured 5% passive income stream, are you one of them? The average American couple has saved this much money for
Benzinga•1d ago
Holding 6 Ethereum (ETH) Could Make You A Millionaire, According to Cathie Wood
With the recent halving and spot exchange-traded funds (ETFs) driving demand, Bitcoin has had the spotlight for much of 2024. However, according to Cathie Wood of Ark Invest, Ethereum (ETH) could catch up to Bitcoin and provide investors with huge profits in the coming years. At an investor conference held by Ark Invest, Wood spoke about Ethereum, noting that the project could reach a market capitalization of $20 trillion by 2032. ETH currently has a supply of around 120 million tokens. So, a ma
Benzinga•5h ago
Super Micro Computer (SMCI) Earnings Expected to Grow: What to Know Ahead of Next Week's Release
Super Micro (SMCI) possesses the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.
Zacks•5h ago
Jamie Dimon is worried the US economy is headed back to the 1970s
JPMorgan's CEO is concerned the US economy could be in for a repeat of the stagflation that hampered the country during the 1970s.
Yahoo Finance•57m ago
Here’s who really benefits from Biden’s $153 billion in student-debt cancellation
New data sheds light on how the Biden administration’s debt-relief efforts have affected borrowers.
MarketWatch•9h ago
Ask an Advisor: We're 56 With $1.2 Million in Investments and Savings. Can We Afford to Withdraw $60k-$80k Per Year in Retirement?
My wife and I are both 56. We have around $1.2 million saved – approximately $450,000 in company 401(k)s, $650,000 in a managed account, and approximately $70,000 in personal stocks. We also have approximately $22,000 in savings. Our home is worth $700,000 or more and we owe $197,000 with a 3.875% interest rate. Our advisor […] The post Ask an Advisor: We’re 56 With $1.2 Million in Investments and Savings. Can We Afford to Withdraw $60k-$80k Per Year in Retirement? appeared first on SmartReads b
SmartAsset•4h ago
It's Time to Ditch These 2 "Magnificent Seven" Stocks and Replace Them With 2 Bona Fide Outperformers
Among Microsoft, Apple, Nvidia, Alphabet, Amazon, Meta Platforms, and Tesla, there are two former highfliers that are no longer magnificent.
Motley Fool•1d ago
Trump poised to clinch $1.3 billion social media company stock award
Donald Trump is set to secure on Tuesday a stock bonus worth $1.3 billion from the company that operates his social media app Truth Social, equivalent to about half the majority stake he already owns in it, thanks to the wild rally in its shares. The award will take the former U.S. President's overall stake in the company, Trump Media & Technology Group (TMTG), to $4.1 billion. While Trump has agreed not to sell any of his TMTG shares before September, the windfall represents a significant boost to his wealth, which Forbes pegs at $4.7 billion.
Reuters•9h ago

News

Life

Entertainment

Finance

Sports

New on Yahoo

Yahoo Finance

Pipeline Progress at OncoGenex

Recommended Stories

Suze Orman Decided To Drop Homeowners Insurance After An Outrageous Quote: '$28,000 For A 2,100-Square-Foot Condo. Are You Kidding Me?'

The IRS says it’s going after wealthy tax cheats. Here’s what new audit stats show.

California McDonald's Franchise Owner Says, 'The Focus Is On Survival' With 'Unprecedented' $20 Per Hour Minimum Wage Forcing Higher Prices

Holding 6 Ethereum (ETH) Could Make You A Millionaire, According to Cathie Wood

Super Micro Computer (SMCI) Earnings Expected to Grow: What to Know Ahead of Next Week's Release

Jamie Dimon is worried the US economy is headed back to the 1970s

Here’s who really benefits from Biden’s $153 billion in student-debt cancellation

Ask an Advisor: We're 56 With $1.2 Million in Investments and Savings. Can We Afford to Withdraw $60k-$80k Per Year in Retirement?

It's Time to Ditch These 2 "Magnificent Seven" Stocks and Replace Them With 2 Bona Fide Outperformers

Trump poised to clinch $1.3 billion social media company stock award