SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
Vaxart, Inc. (VXRT), a clinical-stage biotechnology company developing oral recombinant vaccines that are administered by tablet rather than by injection, today announced the publication of the comprehensive results from a preclinical trial of its chikungunya vaccine in the peer reviewed journal, Vaccine.
The article, titled “An adjuvanted adenovirus 5-based vaccine elicits neutralizing antibodies and protects mice against chikungunya virus-induced footpad swelling,” details the results from a study using Vaxart’s chikungunya vaccine candidate in a preclinical efficacy model.
“These preclinical results demonstrate that our vaccine candidate induced significant neutralizing antibodies against chikungunya virus as well as protective efficacy against virus-induced pathologic changes,” said Sean Tucker, Ph.D., founder and chief scientific officer of Vaxart. “Importantly, we saw reduced footpad swelling, a model for arthritis induction in humans caused by chikungunya infection. There are no approved vaccines or treatments for the estimated one million patients each year infected with chikungunya virus.”
Vaxart develops oral vaccines for a broad range of infections that have a major impact on public health, including vaccines for norovirus and influenza.
Chikungunya is an illness caused by a virus that spreads through mosquito bites. The most common symptoms of chikungunya are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, or rash. The mosquito that carries chikungunya virus bites primarily during the daytime, both indoors and outdoors, and often lives around buildings in urban areas. Patients symptoms usually begin 3—7 days after being bitten by an infected mosquito. Most patients will feel better within a week. In some people, the joint pain may persist for months. Death is rare. People at risk for more severe disease include newborns infected around the time of birth, older adults (≥65 years), and people with medical conditions such as high blood pressure, diabetes, or heart disease. Travelers who go to Africa, Asia, parts of Central and South America, and islands in the Indian Ocean, Western and South Pacific, and Caribbean are at risk.
Vaxart is a clinical-stage biotechnology company focused on developing oral recombinant protein vaccines based on its proprietary oral vaccine platform. Vaxart’s vaccines are designed to generate broad and durable immune responses that protect against a wide range of infectious diseases and may also be useful for the treatment of chronic viral infections and cancer. Vaxart’s vaccines are administered using a convenient room temperature-stable tablet, rather than by injection. Vaxart believes that tablet vaccines are easier to distribute and administer than injectable vaccines and have the potential to significantly increase vaccination rates. Vaxart’s development programs include oral tablet vaccines that are designed to protect against norovirus, seasonal influenza and respiratory syncytial virus (RSV), as well as a therapeutic vaccine for human papillomavirus (HPV).
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