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Ramipril: uses, action, dosage, side effects and brands available

Rita Ghelani
Photo credit: dragana991

From Netdoctor

What is ramipril?

Ramipril is a type of medicine called an ACE inhibitor.

Ramipril is a generic medicine that comes as capsules, tablets and liquid.

Ramipril tablets and capsules are available in four different strengths - 1.25mg, 2.5mg, 5mg and 10mg. Ramipril oral solution is available as 2.5mg/5ml strength.

Ramipril tablets are also available under the brand name Tritace.

Triapin tablets contain ramipril in combination with another medicine called felodipine.

What is ramipril used for?

▪️ High blood pressure.

▪️ Heart failure.

▪️ Improving survival in people who have heart failure after suffering a heart attack.

▪️ Reducing the risk of heart attack, stroke and death due to heart disease, in people with any of the following conditions:

  • a history of heart disease, for example, a people who have had a heart attack, angina, or a previous surgical procedure to improve blood supply to the heart, eg heart bypass (coronary artery bypass graft - CABG), or balloon dilation of blood vessels (percutaneous transluminal coronary angioplasty - PTCA)
  • a history of stroke
  • poor blood circulation in the hands or feet due to hardening of the arteries (peripheral vascular disease)
  • diabetes plus one or more of the following risk factors: high blood pressure, high total cholesterol levels, low HDL cholesterol levels, smoking, or protein in the urine (microalbuminuria - the beginning of diabetic kidney disease).
  • Treating kidney disease or delaying worsening of kidney disease (nephropathy) in people either with or without diabetes.

How does ramipril work?

Ramipril works by blocking the action of a compound in the body called angiotensin converting enzyme (ACE). Normally ACE produces another compound called angiotensin II, as part of the body's natural control of blood pressure. Angiotensin II causes blood vessels to constrict and narrow, which increases the blood pressure.

By blocking the action of ACE, ramipril reduces the production of angiotensin II, which allows the blood vessels to relax and widen. This has the overall effect is to lower blood pressure.

When the pressure within the blood vessels is reduced, the heart doesn't have to work as hard to pump the blood around the body. This means that ACE inhibitors like ramipril can be used to improve the symptoms of heart failure, where the heart isn't pumping as efficiently as it should be.

Ramipril has also been shown to improve survival in people who are diagnosed with heart failure after suffering a heart attack. Ramipril is usually used in combination with a diuretic medicine to treat heart failure.

If left untreated, high blood pressure can damage the heart, blood vessels and kidneys. Ramipril has been shown to have a protective effect on the heart and also helps to reduce the risk of heart, kidney or blood vessel problems in various groups of people who are at risk of these problems.

Read more about ramipril

What should I know before taking ramipril?

How do I take ramipril?

What are the possible side effects of ramipril?

Can I take other medicines with ramipril?

Last updated: 18/06/2019

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