Unai Emery's men currently sit third in the table, but could find themselves sat anywhere between second and eighth come Tuesday depending on other results.
However, Arsenal's away form this season has been a cause for concern, winning just once from four games on the road this season, and they now face a Sheffield United side who so nearly held out for a draw against leaders Liverpool.
The Blades have recorded some impressive results this season, including taking a point away from Stamford Bridge in a 2-2 draw with Chelsea in September.
However, Leicester City and Southampton have also emerged victorious from Bramall Lane this season, leaving the Monday night game finely poised.
When is it?
Kick-off is at 8pm BST on Monday 21st October.
How can I watch it?
The match will be broadcast on Sky Sports Premier League and Main Event from 7pm.
You can also live stream the match via the Sky Go app on a range of devices, including laptops, smartphones and tablets.
Arsenal could welcome back as many as four players to Premier League action for the visit to Sheffield United.
Striker Alexandre Lacazette was back in full training this weekend and while it is unlikely he will be risked from the start, he could be among the substitues.
Hector Bellerin, Rob Holding and Kieran Tierney have all accrued minutes in the Carabao Cup and Europa League this season, but the latter is the most advanced in his recovery and could come in for Sead Kolasinac.
Chris Wilder meanwhile has said he will give injured trio John Fleck, Oli McBurnie and David McGoldrick every opportunity to prove their fitness ahead of the game.
McGoldrick missed Republic of Ireland's Euro 2020 qualifiers with the groin injury, while fellow striker McBurnie pulled out of the Scotland squad with a knee problem.
Sheffield United: Henderson, Basham, Egan, O'Connell, Baldock, Lundstram, Norwood, Osborn, Stevens, Robinson, Mousset
Arsenal: Leno, Chambers, Holding, Luiz, Tierney, Torreira, Xhaka, Guendouzi, Pepe, Aubameyang, Saka
Sheffield United: 11/4
(source: Paddy Power)
Prediction - Sheffield United 1-1 Arsenal
Arsenal's last two Premier League away games have ended in score draws, and a similar fate could be in store for Unai Emery's men in Sheffield.
While they have managed to fathom victory out of nowhere at the Emirates, Emery's side have looked uninspiring for the majority of their games away from north London, except a brilliant first half not far from home at Watford.
Hope remains that Arsenal's play will improve at both ends of the field once Hector Bellerin, Kieran Tierney and Rob Holding return, but regardless of the 11 players to take the field Sheffield United will fancy their chances against a side won just once on the road in four attempts this season.
The Blades came agonisingly close to claiming a point against Liverpool, and having also held Chelsea at Stamford Bridge this season, they could increase their points tally on Monday night as well.