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(Adds Juul's appeal to block FDA ban) June 24 (Reuters) - The U.S. Food and Drug Administration ordered Juul Labs Inc to stop selling its e-cigarettes in the United States on Thursday, saying the company's data "lacked sufficient evidence" to show its products would be appropriate for the protection of public health. The following are significant events in the checkered history of Juul Labs, which started under the name of Ploom Inc: Date/Year Event 2007 Product Design graduates of Stanford University, James Monsees and Adam Bowen, found Ploom Inc, drawing from their thesis project on a new kind of cigarette. 2012 Ploom introduces a line of vaporizers called Pax, designed to heat up loose-leaf tobacco but instead became enormously popular as discreet devices for using cannabis. 2015 Ploom becomes Pax Labs after selling the rights of its products to Japan Tobacco International, an investor in the company. 2015 Pax Labs introduces Juul e-cigarette. 2017 Pax Labs spins out into a separate company, leaving Juul Labs to focus on nicotine e-cigarettes. Dec. 2017 Juul names former Chobani executive Kevin Burns as its new chief executive. April 2018 The U.S. Food and Drug Administration says it has conducted an investigation of underage sales of Juul products and writes to Juul requesting documents around the marketing of its products. April 2018 Juul announces it will take more decisive action by supporting state and federal push to raise the minimum age to 21+ to purchase tobacco products. Sept. 2018 Then-FDA Commissioner Scott Gottlieb calls teenage vaping an "epidemic," tells Juul and other e-cigarette makers they have 60 days to submit plans on ways to combat youth use. Nov. 2018 Juul announces plans to pull all flavors from over 90,000 retail stores except tobacco, mint and menthol; the FDA says it will craft similar regulations around those flavors. (https://reut.rs/3yd7xTj) Dec. 2018 Tobacco giant Altria Group invests $12.8 billion in Juul, taking a 35% stake in Juul and valuing the company at $38 billion. (https://reut.rs/3HMAZms) Sept. 9, The FDA sends warning letter to Juul CEO over 2019 its unproven claims that its products pose less harm than traditional cigarettes. Sept. 11, Trump administration says it will ban the sale 2019 of most flavored e-cigarettes. Sept. 25, CEO Kevin Burns steps down. Juul names former 2019 Altria executive KC Crosthwaite as CEO. Also suspends all advertising in the U.S. and says it will refrain from lobbying the Trump administration. (https://reut.rs/3xSpFR0)(https://reut.rs/3zY5SCp) Oct. 17, Juul suspends sale of its non-tobacco, 2019 non-menthol-based flavors Mango, Creme, Fruit and Cucumber in the United States pending FDA review. (https://reut.rs/3OFYEHD) Oct. 31, Altria says it is writing down its investment in 2019 Juul by $4.5 billion, citing regulatory risks. (https://reut.rs/3bmGxbk) Nov. 12, Juul to cut nearly $1 billion in costs next 2019 year. (https://reut.rs/3NfoGjI) Nov. 19, The state of California sues Juul, alleging the 2019 San Francisco company engaged in a "systematic" and "wildly successful" campaign to woo teenagers to its nicotine devices. (https://reut.rs/3HTgXGX) Jan. 2, Trump administration bans some popular 2020 e-cigarette flavors including fruit and mint, allowing only menthol and tobacco flavors to remain on the market. (https://reut.rs/3bpKkEs) Jan. 20, Altria takes a $4 billion charge on its 2020 investment in Juul, bringing down the value of its investment to $4.2 billion as of the end of 2019. (https://reut.rs/3bh7flv) Feb. 21, The U.S. Securities and Exchange Commission 2020 probes Altria's investment in Juul. (https://reut.rs/3ncaPQM) March 12, Juul announces co-founder James Monsees to leave 2020 the e-cigarette maker, stepping down as adviser and board member. (https://reut.rs/3yeQpg6) April 1, The U.S. Federal Trade Commission files a 2020 complaint to force Altria to sell its investment in e-cigarette maker Juul. (https://reut.rs/3HMuT5y) July 30, Juul Labs submits a Premarket Tobacco Product 2020 Application to the FDA for its JUUL System, an electronic nicotine delivery system. (https://reut.rs/3bmzwqG) Aug. 18, The FDA files Juul's PMTA for substantive 2020 review. Sept. 3, Juul says it will cut global workforce 2020 significantly and consider pulling out of some European and Asia-Pacific markets. (https://reut.rs/3nctiwq) Oct. 29, Juul cut its valuation to about $10 billion from 2020 $12 billion at the end of last year as it faces regulatory scrutiny. (https://reut.rs/3bfVNq9) Oct. 30, Altria takes another hit of $2.6 billion to its 2020 investment in Juul. Its stake is now worth $1.6 billion. (https://reut.rs/3QJxy3W) Sept. 9, The FDA says it needs more time to decide if 2021 e-cigarette maker Juul and other major manufacturers can sell products in the United States. Feb. 15, A judge at the FTC dismisses a complaint that 2022 the agency filed aimed at requiring Altria to sell a minority investment in Juul. April 28, The FDA issues a proposal to ban menthol 2022 cigarettes and flavored cigars, a year after the agency announced the plan. June 22, Wall Street Journal reports the FDA is preparing 2022 to order Juul to take its e-cigarettes off the U.S. market. June 23, The FDA blocks Juul from selling its nicotine 2022 products in the United States, after a nearly two-year-long review of data submitted by the company. June 24, Juul asks a federal appeals court to temporarily 2022 block the FDA's order to stop selling its e-cigarettes in the United States, according to a filing with the U.S. Court of Appeals for the D.C. Circuit. (Reporting by Ananya Mariam Rajesh in Bengaluru; Editing by Arun Koyyur and Shounak Dasgupta)